Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine

G. Tolva; S. Gandini; M. Marabelli; M. Calvello; A. Guerrieri-Gonzaga; L. Bertario; B. Bonanni

doi:10.1038/s41436-019-0716-6

Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine

G. Tolva, S. Gandini, M. Marabelli, M. Calvello, A. Guerrieri-Gonzaga, L. Bertario, B. Bonanni

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	811-812
Number of pages	2
Journal	Gen. Med.
Volume	22
Issue number	4
DOIs	https://doi.org/10.1038/s41436-019-0716-6
Publication status	Published - 2020

Keywords

DNA mismatch repair protein MSH2
MutL protein homolog 1
age
breast cancer
cancer diagnosis
cancer registry
cancer risk
cancer screening
clinical practice
gender
genetic analysis
genetic association
genetic variability
hereditary nonpolyposis colorectal cancer
heterozygote
human
Letter
mismatch repair
MSH2 gene
patient coding
practice guideline
prospective study
risk assessment
genetics
information processing
Colorectal Neoplasms, Hereditary Nonpolyposis
Data Management
DNA Mismatch Repair
Humans
MutL Protein Homolog 1
Prospective Studies

Access to Document

10.1038/s41436-019-0716-6

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075980532&doi=10.1038%2fs41436-019-0716-6&partnerID=40&md5=28071e5de3c8b5befb41511b17fad946

Cite this

Tolva, G., Gandini, S., Marabelli, M., Calvello, M., Guerrieri-Gonzaga, A., Bertario, L., & Bonanni, B. (2020). Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine. Gen. Med., 22(4), 811-812. https://doi.org/10.1038/s41436-019-0716-6

Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database : Genetics in Medicine. / Tolva, G.; Gandini, S.; Marabelli, M. et al.

In: Gen. Med., Vol. 22, No. 4, 2020, p. 811-812.

Research output: Contribution to journal › Article › peer-review

Tolva, G, Gandini, S, Marabelli, M , Calvello, M , Guerrieri-Gonzaga, A, Bertario, L & Bonanni, B 2020, 'Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine', Gen. Med., vol. 22, no. 4, pp. 811-812. https://doi.org/10.1038/s41436-019-0716-6

Tolva G, Gandini S, Marabelli M , Calvello M , Guerrieri-Gonzaga A, Bertario L et al. Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine. Gen. Med. 2020;22(4):811-812. https://doi.org/10.1038/s41436-019-0716-6

@article{78e5e91c2fad47d1a68007c458a58761,

title = "Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database: Genetics in Medicine",

keywords = "DNA mismatch repair protein MSH2, MutL protein homolog 1, age, breast cancer, cancer diagnosis, cancer registry, cancer risk, cancer screening, clinical practice, gender, genetic analysis, genetic association, genetic variability, hereditary nonpolyposis colorectal cancer, heterozygote, human, Letter, mismatch repair, MSH2 gene, patient coding, practice guideline, prospective study, risk assessment, genetics, information processing, Colorectal Neoplasms, Hereditary Nonpolyposis, Data Management, DNA Mismatch Repair, Humans, MutL Protein Homolog 1, Prospective Studies",

author = "G. Tolva and S. Gandini and M. Marabelli and M. Calvello and A. Guerrieri-Gonzaga and L. Bertario and B. Bonanni",

note = "Cited By :1 Export Date: 5 March 2021 CODEN: GEMEF Correspondence Address: Tolva, G.; Division of Cancer Prevention and Genetics, Italy; email: gianluca.tolva@ieo.it Chemicals/CAS: DNA mismatch repair protein MSH2, 153700-72-2; MutL protein homolog 1, 155577-96-1; MutL Protein Homolog 1 References: Dominguez-Valentin, M., Sampson, J., Sepp{\"a}l{\"a}, T., Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: Findings from the Prospective Lynch Syndrome Database (2019) Genet Med, , https://doi.org/10.1038/s41436-019-0596-9, Jul 24, Epub ahead of print; Win, A.K., Lindor, N.M., Jenkins, M.A., Risk of breast cancer in Lynch syndrome: a systematic review (2013) Breast Cancer Res., 15; Win, A.K., Young, J.P., Lindor, N.M., Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study (2012) J Clin Oncol, 30, pp. 958-964; Engel, C., Loeffler, M., Steinke, V., Risks of less common cancers in proven mutation carriers with lynch syndrome (2012) J Clin Oncol, 30, pp. 4409-4415; Pande, M., Wei, C., Chen, J., Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry (2012) Fam Cancer, 11, pp. 441-447; Win, A.K., Lindor, N.M., Young, J.P., Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome (2012) J Natl Cancer Inst, 104, pp. 1363-1372; Win, A.K., Lindor, N.M., Winship, I., Risks of Colorectal and Other Cancers After Endometrial Cancer for Women With Lynch Syndrome (2013) J Natl Cancer Inst, 105, pp. 274-279; Harkness, E.F., Barrow, E., Newton, K., Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study (2015) J Med Genet, 52, pp. 553-556; Goldberg, M., Bell, K., Aronson, M., Association between the Lynch syndrome gene MSH2 and breast cancer susceptibility in a Canadian familial cancer registry (2017) J Med Genet, 54, pp. 742-746; Therkildsen, C., Ladelund, S., Smith-Hansen, L., Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types (2017) Br J Cancer, 117, pp. 1702-1710; M{\o}ller, P., Sepp{\"a}l{\"a}, T.T., Bernstein, I., Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database (2018) Gut., 67, pp. 1306-1316; M{\o}ller, P., Sepp{\"a}l{\"a}, T., Bernstein, I., Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the Prospective Lynch Syndrome Database (2017) Gut., 66, pp. 464-472; Stjepanovic, N., Moreira, L., Carneiro, F., Hereditary gastrointestinal cancers: ESMO clinical practice guidelines for diagnosis, treatment and follow-up (2019) Ann Oncol, 30, pp. 1558-1571; Gupta, S., Provenzale, D., Llor, X., NCCN guidelines insights: genetic/familial high-risk assessment: colorectal, version 2.2019 (2019) J Natl Compr Cancer Netw, 17, pp. 1032-1041",

year = "2020",

doi = "10.1038/s41436-019-0716-6",

language = "English",

volume = "22",

pages = "811--812",

journal = "Gen. Med.",

issn = "1098-3600",

publisher = "Springer Nature",

number = "4",

}

TY - JOUR

T1 - Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

T2 - Genetics in Medicine

AU - Tolva, G.

AU - Gandini, S.

AU - Marabelli, M.

AU - Calvello, M.

AU - Guerrieri-Gonzaga, A.

AU - Bertario, L.

AU - Bonanni, B.

N1 - Cited By :1 Export Date: 5 March 2021 CODEN: GEMEF Correspondence Address: Tolva, G.; Division of Cancer Prevention and Genetics, Italy; email: gianluca.tolva@ieo.it Chemicals/CAS: DNA mismatch repair protein MSH2, 153700-72-2; MutL protein homolog 1, 155577-96-1; MutL Protein Homolog 1 References: Dominguez-Valentin, M., Sampson, J., Seppälä, T., Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: Findings from the Prospective Lynch Syndrome Database (2019) Genet Med, , https://doi.org/10.1038/s41436-019-0596-9, Jul 24, Epub ahead of print; Win, A.K., Lindor, N.M., Jenkins, M.A., Risk of breast cancer in Lynch syndrome: a systematic review (2013) Breast Cancer Res., 15; Win, A.K., Young, J.P., Lindor, N.M., Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study (2012) J Clin Oncol, 30, pp. 958-964; Engel, C., Loeffler, M., Steinke, V., Risks of less common cancers in proven mutation carriers with lynch syndrome (2012) J Clin Oncol, 30, pp. 4409-4415; Pande, M., Wei, C., Chen, J., Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry (2012) Fam Cancer, 11, pp. 441-447; Win, A.K., Lindor, N.M., Young, J.P., Risks of primary extracolonic cancers following colorectal cancer in Lynch syndrome (2012) J Natl Cancer Inst, 104, pp. 1363-1372; Win, A.K., Lindor, N.M., Winship, I., Risks of Colorectal and Other Cancers After Endometrial Cancer for Women With Lynch Syndrome (2013) J Natl Cancer Inst, 105, pp. 274-279; Harkness, E.F., Barrow, E., Newton, K., Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study (2015) J Med Genet, 52, pp. 553-556; Goldberg, M., Bell, K., Aronson, M., Association between the Lynch syndrome gene MSH2 and breast cancer susceptibility in a Canadian familial cancer registry (2017) J Med Genet, 54, pp. 742-746; Therkildsen, C., Ladelund, S., Smith-Hansen, L., Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types (2017) Br J Cancer, 117, pp. 1702-1710; Møller, P., Seppälä, T.T., Bernstein, I., Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database (2018) Gut., 67, pp. 1306-1316; Møller, P., Seppälä, T., Bernstein, I., Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the Prospective Lynch Syndrome Database (2017) Gut., 66, pp. 464-472; Stjepanovic, N., Moreira, L., Carneiro, F., Hereditary gastrointestinal cancers: ESMO clinical practice guidelines for diagnosis, treatment and follow-up (2019) Ann Oncol, 30, pp. 1558-1571; Gupta, S., Provenzale, D., Llor, X., NCCN guidelines insights: genetic/familial high-risk assessment: colorectal, version 2.2019 (2019) J Natl Compr Cancer Netw, 17, pp. 1032-1041

PY - 2020

Y1 - 2020

KW - DNA mismatch repair protein MSH2

KW - MutL protein homolog 1

KW - age

KW - breast cancer

KW - cancer diagnosis

KW - cancer registry

KW - cancer risk

KW - cancer screening

KW - clinical practice

KW - gender

KW - genetic analysis

KW - genetic association

KW - genetic variability

KW - hereditary nonpolyposis colorectal cancer

KW - heterozygote

KW - human

KW - Letter

KW - mismatch repair

KW - MSH2 gene

KW - patient coding

KW - practice guideline

KW - prospective study

KW - risk assessment

KW - genetics

KW - information processing

KW - Colorectal Neoplasms, Hereditary Nonpolyposis

KW - Data Management

KW - DNA Mismatch Repair

KW - Humans

KW - MutL Protein Homolog 1

KW - Prospective Studies

U2 - 10.1038/s41436-019-0716-6

DO - 10.1038/s41436-019-0716-6

M3 - Article

VL - 22

SP - 811

EP - 812

JO - Gen. Med.

JF - Gen. Med.

SN - 1098-3600

IS - 4

ER -