Response to first-line chemotherapy and long-term survival in patients with multiple myeloma: Results of the MM87 prospective randomised protocol

A. Riccardi, O. Mora, C. Tinelli, C. Porta, M. Danova, S. Brugnatelli, D. Grasso, B. Tolcà, R. Spanedda, A. De Paoli, L. Barbarano, L. Cavanna, M. Giordano, C. Delfini, G. Nicoletti, C. Bergonzi, E. Rinaldi, L. Piccinini, E. Ascari

Research output: Contribution to journalArticle

Abstract

In this study we evaluated whether a good response to conventional chemotherapy, i.e. a significant tumour reduction, is a prerequisite for improved survival in multiple myeloma (MM). Between January 1987 and March 1990, 341 consecutive previously untreated patients with MM received chemotherapy within the prospective, multicentre, randomised Protocol MM87. Of these, 258 patients were evaluable for both response and long-term survival and 244 (94.6%) have died. The median survival of all patients was 40 months (6-162 months). The median survival did not differ between patients who had complete response (CR) (50 months (9-162 months)), partial response (PR) (46 months (8-147 months)) or stable disease (SD) (41 months (7-135 months)). The median survival was shorter (13.6 months (6-135 months)) (P

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalEuropean Journal of Cancer
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2003

Keywords

  • Conventional chemotherapy
  • Multiple myeloma
  • Response
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Riccardi, A., Mora, O., Tinelli, C., Porta, C., Danova, M., Brugnatelli, S., Grasso, D., Tolcà, B., Spanedda, R., De Paoli, A., Barbarano, L., Cavanna, L., Giordano, M., Delfini, C., Nicoletti, G., Bergonzi, C., Rinaldi, E., Piccinini, L., & Ascari, E. (2003). Response to first-line chemotherapy and long-term survival in patients with multiple myeloma: Results of the MM87 prospective randomised protocol. European Journal of Cancer, 39(1), 31-37. https://doi.org/10.1016/S0959-8049(02)00529-4