Abstract
Aim. To determine activity and toxicity of high-dose ifosfamide (HDIFO) in recurrent or advanced Ewing sarcoma family tumors (EFT). Methods. Thirty-seven EFT patients [median age 17 years (645 years)] previously treated with chemotherapy regimens including standard dose ifosfamide were enrolled. HDIFO was administered for metastatic recurrent disease in 33 patients and for progression during neoadjuvant chemotherapy in 4 patients. All patients who received two courses of 15 g/m2 ifosfamide were evaluable for radiographic response assessed according to RECIST criteria. Results. Transient Grade 4 neutropenia and thrombocytopenia in 97% and 54% HDIFO courses respectively and severe CNS toxicity in one patient were observed. Thirty-five patients were evaluable: 12 (34%) had complete (2) or partial (10) response, 11 (32%) had stable disease, and 12 (34%) had progression. Conclusions. In patients with relapsed or advanced EFT previously treated with standard dose ifosfamide HDIFO is active and it should be considered a treatment option.
Original language | English |
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Pages (from-to) | 581-584 |
Number of pages | 4 |
Journal | Pediatric Blood and Cancer |
Volume | 52 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2009 |
Keywords
- Ewing sarcoma family tumors
- High-dose ifosfamide
- Radiographic response
- Toxicity
ASJC Scopus subject areas
- Medicine(all)
- Hematology
- Oncology
- Pediatrics, Perinatology, and Child Health