Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer

D. D'Ugo, R. Persiani, S. Rausei, A. Biondi, V. Vigorita, S. Boccia, R. Ricci

Research output: Contribution to journalArticlepeer-review


Aims: Aim of this study is the evaluation of the effects induced by neoadjuvant chemotherapy (NACT) and its impact on survival on a series of locally advanced gastric carcinomas. Methods: Downstaging was assessed comparing pre-treatment clinical and laparoscopic staging with post-operative pathologic staging on 30 consecutive patients who completed a 3-year follow-up. Tumor downstaging and the grade of pathologic response were included in a statistical correlation between tumor regression induced by NACT and 3-year survival. Results: In this series tumor downstaging was obtained in 13 out of 30 patients. After the completion of 3-year follow-up, overall survival was >37.5 months with an overall survival rate of 56.7%; this figure reached up to 70.8% in those cases who benefited from a R0-resection (24/30 patients: R0-resection rate 80.0%). Conclusions: In this study the 3-year survival for locally advanced gastric cancer treated by NACT prior to "D2" surgical resection, compares favourably with historical series treated by surgery alone. Patients who obtained T-downstaging and subsequently benefited from a R0-resection had a definitely better chance of cure, according to a complete 3-year follow-up.

Original languageEnglish
Pages (from-to)1105-1109
Number of pages5
JournalEuropean Journal of Surgical Oncology
Issue number10
Publication statusPublished - Dec 2006


  • Laparoscopic staging
  • Locally advanced gastric cancer
  • Neoadjuvant chemotherapy
  • Pathologic response
  • Tumor downstaging

ASJC Scopus subject areas

  • Oncology
  • Surgery


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