TY - JOUR
T1 - Response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C due to genotype 4
AU - Martín-Carbonero, L.
AU - Puoti, M.
AU - García-Samaniego, J.
AU - De Luca, A.
AU - Losada, E.
AU - Quinzan, G.
AU - Bruno, R.
AU - Mariño, A.
AU - González, M.
AU - Núñez, M.
AU - Soriano, V.
PY - 2008/10
Y1 - 2008/10
N2 - Hepatitis C virus (HCV) genotypes 1 and 4 respond less well to pegylated interferon (pegIFN) plus ribavirin (RBV) therapy. For this reason most studies merge these two genotypes when assessing virological response. However, in most trials the HCV genotype 4 population is rather small, and conclusions are mainly derived from what occurs in HCV-1 patients. All HCV-4 patients coinfected with HIV who received pegIFN plus RBV in two different multicentre studies, PRESCO and ROMANCE, conducted respectively in Spain and Italy, were retrospectively analyzed. Baseline plasma HCV-RNA, proportion of patients with HCV-RNA 2 logs at week 12 (early virological response, EVR) were all assessed as predictors of sustained virological response (SVR). Overall, 75 patients (60 men) were evaluated. Median age was 40 years and median CD4 count 598 cells/mm 3; 49% had plasma HIV-RNA
AB - Hepatitis C virus (HCV) genotypes 1 and 4 respond less well to pegylated interferon (pegIFN) plus ribavirin (RBV) therapy. For this reason most studies merge these two genotypes when assessing virological response. However, in most trials the HCV genotype 4 population is rather small, and conclusions are mainly derived from what occurs in HCV-1 patients. All HCV-4 patients coinfected with HIV who received pegIFN plus RBV in two different multicentre studies, PRESCO and ROMANCE, conducted respectively in Spain and Italy, were retrospectively analyzed. Baseline plasma HCV-RNA, proportion of patients with HCV-RNA 2 logs at week 12 (early virological response, EVR) were all assessed as predictors of sustained virological response (SVR). Overall, 75 patients (60 men) were evaluated. Median age was 40 years and median CD4 count 598 cells/mm 3; 49% had plasma HIV-RNA
KW - HCV genotype 4
KW - Hepatitis C
KW - HIV
KW - Liver
KW - Pegylated interferon
KW - Ribavirin
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U2 - 10.1111/j.1365-2893.2008.01015.x
DO - 10.1111/j.1365-2893.2008.01015.x
M3 - Article
C2 - 18637070
AN - SCOPUS:52149084563
VL - 15
SP - 710
EP - 715
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
SN - 1352-0504
IS - 10
ER -