Response to raltegravir-based salvage therapy in HIV-infected patients with hepatitis C virus or hepatitis B virus coinfection

Liliana Elena Weimer, Vincenzo Fragola, Marco Floridia, Giovanni Guaraldi, Nicoletta Ladisa, Daniela Francisci, Rita Bellagamba, Anna Degli Antoni, Giustino Parruti, Andrea Giacometti, Paolo Emilio Manconi, Angela Vivarelli, Gabriella D'Ettorre, Maria Stella Mura, Stefania Cicalini, Roberta Preziosi, Laura Sighinolfi, Gabriella Verucchi, Raffaella Libertone, Marcello TavioLoredana Sarmati, Raffaella Bucciardini, G. Angarano, A. Volpe, V. Vullo, G. Ceccarelli, M. Andreoni, D. Delle Rose, V. Tozzi, P. Narciso, N. Petrosillo, V. Pucillo, C. Tommasi, D. Segala, O. Armignacco, C. Ferrari, A. Cavalli, F. Sozio, L. Cosentino, F. Ortu, P. Viale, S. Tedeschi, R. Manfredi, M. Mannazzu, G. Cattari, R. Del Gobbo, A. Mataloni Paggi, O. Cirioni, E. Marchionni, C. Silvestri, L. Brescini, S. Sebastianelli, F. Baldelli, A. Mercuri, S. Bastianelli, G. Nardini, M. Massella, S. Baroncelli, C. M. Galluzzo, M. F. Pirillo, M. G. Mancini, R. Amici, A. Cara, R. Bona, P. Leone, P. Filati, M. Franco, S. Donnini

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To define the impact of coinfection with hepatitis B virus (HBV) or hepatitis C virus (HCV) on viroimmunological response to raltegravir-based salvage regimens that also include new HIV inhibitors such as maraviroc, darunavir and etravirine. Methods: We used data from a national observational study of patients starting raltegravir-based regimens to compare virological suppression and CD4 cell change from baseline in patients with and without concomitant HBV or HCV infection. Results: Overall, 275 patients (107 coinfected and 168 non-coinfected) were evaluated. Coinfected patients were more commonly former intravenous drug users and had a longer history of HIV infection and higher baseline aminotransferase levels. Both HIV-RNA and CD4 response were similar in the two groups. Mean time to first HIV-RNA copy number

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Antiretroviral therapy
  • CD4 response
  • Darunavir
  • Etravirine
  • HBV
  • HCV
  • HIV resistance
  • HIV-1
  • Integrase inhibitors
  • Liver disease
  • Maraviroc
  • Viral hepatitis
  • Viral load

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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