Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments

Teresa Battaglia; Elisa De Grandis; Marisol Mirabelli-Badenier; Luca Boeri; Guido Morcaldi; Paola Barabino; Chiara Intra; Francesca Naselli; Vito Pistoia; Edvige Veneselli; Massimo Conte

doi:10.1016/j.ejpn.2011.05.013

Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments

Teresa Battaglia, Elisa De Grandis, Marisol Mirabelli-Badenier, Luca Boeri, Guido Morcaldi, Paola Barabino, Chiara Intra, Francesca Naselli, Vito Pistoia, Edvige Veneselli, Massimo Conte

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article

Abstract

We report the 1 year follow-up of 3 children affected by non-paraneoplastic Opsoclonus-Myoclonus Syndrome (OMS) resistant to conventional therapies (steroids, ACTH and intravenous immunoglobulins) who were treated with an anti CD20 monoclonal antibody (rituximab). Treatment response was recorded on the basis of an international score at 0, 3, 6, 9 and 12 months. Despite the long disease duration and the numerous previously administered treatments, all patients underwent rapid and persistent neurological recovery following rituximab administration, thus suggesting a potential role of this drug even in pre-treated patients.

Original language	English
Pages (from-to)	192-195
Number of pages	4
Journal	European Journal of Paediatric Neurology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.ejpn.2011.05.013
Publication status	Published - Mar 2012

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Keywords

Opsoclonus-myoclonus syndrome
Paraneoplastic syndromes
Rituximab
Treatment

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health

Cite this

Battaglia, T., De Grandis, E., Mirabelli-Badenier, M., Boeri, L., Morcaldi, G., Barabino, P., Intra, C., Naselli, F., Pistoia, V., Veneselli, E., & Conte, M. (2012). Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments. European Journal of Paediatric Neurology, 16(2), 192-195. https://doi.org/10.1016/j.ejpn.2011.05.013

Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments. / Battaglia, Teresa; De Grandis, Elisa; Mirabelli-Badenier, Marisol; Boeri, Luca; Morcaldi, Guido; Barabino, Paola; Intra, Chiara; Naselli, Francesca; Pistoia, Vito; Veneselli, Edvige; Conte, Massimo.

In: European Journal of Paediatric Neurology, Vol. 16, No. 2, 03.2012, p. 192-195.

Research output: Contribution to journal › Article

Battaglia, T, De Grandis, E, Mirabelli-Badenier, M, Boeri, L, Morcaldi, G, Barabino, P, Intra, C, Naselli, F, Pistoia, V, Veneselli, E & Conte, M 2012, 'Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments', European Journal of Paediatric Neurology, vol. 16, no. 2, pp. 192-195. https://doi.org/10.1016/j.ejpn.2011.05.013

Battaglia, Teresa ; De Grandis, Elisa ; Mirabelli-Badenier, Marisol ; Boeri, Luca ; Morcaldi, Guido ; Barabino, Paola ; Intra, Chiara ; Naselli, Francesca ; Pistoia, Vito ; Veneselli, Edvige ; Conte, Massimo. / Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments. In: European Journal of Paediatric Neurology. 2012 ; Vol. 16, No. 2. pp. 192-195.

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10.1016/j.ejpn.2011.05.013