Abstract
Interferon-γ release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests cannot discriminate between recently acquired infection (higher risk of progression to active tuberculosis) and remote LTBI. The objective of the present study was to evaluate the T-cell interferon-γ responses to Mycobacterium tuberculosis DosR-regulon-encoded antigens (latency antigens) compared with QuantiFERON TB-Gold In-Tube (QFT-GIT) in subjects at different stages of tuberculosis. A total of 16 individuals with remote LTBI and 23 with recent infection were studied; 15 controls unexposed to M. tuberculosis and 50 patients with active tuberculosis and 45 with cured tuberculosis were also analysed. The results indicated that subjects with remote LTBI showed significantly higher whole-blood interferon-γ responses to M. tuberculosis latency antigen Rv2628 than did individuals with recent infection, active tuberculosis and controls (p
| Original language | English |
|---|---|
| Pages (from-to) | 135-142 |
| Number of pages | 8 |
| Journal | European Respiratory Journal |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Diagnostics
- Dormancy
- Recent tuberculosis infection
- Remote latent tuberculosis infection
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Medicine(all)
Cite this
Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection. / Goletti, D.; Butera, O.; Vanini, V.; Lauria, F. N.; Lange, C.; Franken, K. L M C; Angeletti, C.; Ottenhoff, T. H M; Girardi, E.
In: European Respiratory Journal, Vol. 36, No. 1, 2010, p. 135-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection
AU - Goletti, D.
AU - Butera, O.
AU - Vanini, V.
AU - Lauria, F. N.
AU - Lange, C.
AU - Franken, K. L M C
AU - Angeletti, C.
AU - Ottenhoff, T. H M
AU - Girardi, E.
PY - 2010
Y1 - 2010
N2 - Interferon-γ release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests cannot discriminate between recently acquired infection (higher risk of progression to active tuberculosis) and remote LTBI. The objective of the present study was to evaluate the T-cell interferon-γ responses to Mycobacterium tuberculosis DosR-regulon-encoded antigens (latency antigens) compared with QuantiFERON TB-Gold In-Tube (QFT-GIT) in subjects at different stages of tuberculosis. A total of 16 individuals with remote LTBI and 23 with recent infection were studied; 15 controls unexposed to M. tuberculosis and 50 patients with active tuberculosis and 45 with cured tuberculosis were also analysed. The results indicated that subjects with remote LTBI showed significantly higher whole-blood interferon-γ responses to M. tuberculosis latency antigen Rv2628 than did individuals with recent infection, active tuberculosis and controls (p
AB - Interferon-γ release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests cannot discriminate between recently acquired infection (higher risk of progression to active tuberculosis) and remote LTBI. The objective of the present study was to evaluate the T-cell interferon-γ responses to Mycobacterium tuberculosis DosR-regulon-encoded antigens (latency antigens) compared with QuantiFERON TB-Gold In-Tube (QFT-GIT) in subjects at different stages of tuberculosis. A total of 16 individuals with remote LTBI and 23 with recent infection were studied; 15 controls unexposed to M. tuberculosis and 50 patients with active tuberculosis and 45 with cured tuberculosis were also analysed. The results indicated that subjects with remote LTBI showed significantly higher whole-blood interferon-γ responses to M. tuberculosis latency antigen Rv2628 than did individuals with recent infection, active tuberculosis and controls (p
KW - Diagnostics
KW - Dormancy
KW - Recent tuberculosis infection
KW - Remote latent tuberculosis infection
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=77954642578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954642578&partnerID=8YFLogxK
U2 - 10.1183/09031936.00140009
DO - 10.1183/09031936.00140009
M3 - Article
C2 - 19926735
AN - SCOPUS:77954642578
VL - 36
SP - 135
EP - 142
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 1
ER -