Response to SSRIs and role of the hormonal therapy in post-menopausal depression

R. Zanardi, D. Rossini, L. Magri, A. Malaguti, C. Colombo, E. Smeraldi

Research output: Contribution to journalArticlepeer-review


The aim of this study is to prospectively evaluate the antidepressant response to SSRIs in depressed post-menopausal women with or without hormonal therapy (HT), and to analyze the possible influence of basal serum levels of gonadotropins and sexual hormones on the antidepressant response. 170 post-menopausal women with a depressive episode (DSM-IV criteria) - 47 on HT and 123 not on HT - started the treatment with an SSRI. Depressive symptoms were assessed at baseline and 7 weeks thereafter by raters blind to treatment regimen. Response rates were 63.2% in the group without HT and 83.7% in the HT group (p = 0.013). An inverse correlation emerged between the basal levels of LH and the improvement in HRSD scores (p = 0.001) in the group without HT. In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalEuropean Neuropsychopharmacology
Issue number6-7
Publication statusPublished - May 2007


  • Antidepressant response
  • Depression
  • Hormonal therapy
  • Menopause
  • SSRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)


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