Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders

Rolando Cimaz, E. Meregalli, M. Biggioggero, P. Airò, E. Danieli, C. M. Antonioli, M. Motta, G. Chirico, D. Columbrita, M. Frassi, P. L. Meroni, A. Tincani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetani toxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalLupus
Volume16
Issue number2
DOIs
Publication statusPublished - 2007

Fingerprint

Tetanus
Immunosuppressive Agents
Vaccination
Mothers
Autoimmune Diseases
Tetanus Toxoid
Pharmaceutical Preparations
Pregnancy
Placenta
Aspirin
Antibody Formation
Immune System
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Newborn Infant
Antibodies
Therapeutics

Keywords

  • Immune function
  • Immunosuppression
  • Newborns
  • Pregnancy
  • Vaccination

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Cimaz, R., Meregalli, E., Biggioggero, M., Airò, P., Danieli, E., Antonioli, C. M., ... Tincani, A. (2007). Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders. Lupus, 16(2), 129-132. https://doi.org/10.1177/0961203306075738

Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders. / Cimaz, Rolando; Meregalli, E.; Biggioggero, M.; Airò, P.; Danieli, E.; Antonioli, C. M.; Motta, M.; Chirico, G.; Columbrita, D.; Frassi, M.; Meroni, P. L.; Tincani, A.

In: Lupus, Vol. 16, No. 2, 2007, p. 129-132.

Research output: Contribution to journalArticle

Cimaz, R, Meregalli, E, Biggioggero, M, Airò, P, Danieli, E, Antonioli, CM, Motta, M, Chirico, G, Columbrita, D, Frassi, M, Meroni, PL & Tincani, A 2007, 'Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders', Lupus, vol. 16, no. 2, pp. 129-132. https://doi.org/10.1177/0961203306075738
Cimaz, Rolando ; Meregalli, E. ; Biggioggero, M. ; Airò, P. ; Danieli, E. ; Antonioli, C. M. ; Motta, M. ; Chirico, G. ; Columbrita, D. ; Frassi, M. ; Meroni, P. L. ; Tincani, A. / Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders. In: Lupus. 2007 ; Vol. 16, No. 2. pp. 129-132.
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