Abstract
We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 864-866 |
| Number of pages | 3 |
| Journal | Pediatric Blood and Cancer |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2007 |
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Keywords
- Desmoplastic small round cell tumor
- Low-dose cyclophosphamide
- Metronomic therapy
- Vinorelbine
ASJC Scopus subject areas
- Cancer Research
- Pediatrics, Perinatology, and Child Health
- Hematology
Cite this
Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor. / Ferrari, Andrea; Grosso, Federica; Stacchiotti, Silvia; Meazza, Cristina; Zaffignani, Elena; Marchianò, Alfonso; Casanova, Michela.
In: Pediatric Blood and Cancer, Vol. 49, No. 6, 11.2007, p. 864-866.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor
AU - Ferrari, Andrea
AU - Grosso, Federica
AU - Stacchiotti, Silvia
AU - Meazza, Cristina
AU - Zaffignani, Elena
AU - Marchianò, Alfonso
AU - Casanova, Michela
PY - 2007/11
Y1 - 2007/11
N2 - We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.
AB - We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.
KW - Desmoplastic small round cell tumor
KW - Low-dose cyclophosphamide
KW - Metronomic therapy
KW - Vinorelbine
UR - http://www.scopus.com/inward/record.url?scp=34948890470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34948890470&partnerID=8YFLogxK
U2 - 10.1002/pbc.20682
DO - 10.1002/pbc.20682
M3 - Article
C2 - 16302215
AN - SCOPUS:34948890470
VL - 49
SP - 864
EP - 866
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 6
ER -