We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.
- Desmoplastic small round cell tumor
- Low-dose cyclophosphamide
- Metronomic therapy
ASJC Scopus subject areas
- Cancer Research
- Pediatrics, Perinatology, and Child Health