Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

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Abstract

We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

Original languageEnglish
Pages (from-to)864-866
Number of pages3
JournalPediatric Blood and Cancer
Volume49
Issue number6
DOIs
Publication statusPublished - Nov 2007

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Desmoplastic Small Round Cell Tumor
Cyclophosphamide
Drug Therapy
Rhabdomyosarcoma
Residual Neoplasm
Therapeutics
vinorelbine

Keywords

  • Desmoplastic small round cell tumor
  • Low-dose cyclophosphamide
  • Metronomic therapy
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

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title = "Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor",
abstract = "We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.",
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T1 - Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

AU - Ferrari, Andrea

AU - Grosso, Federica

AU - Stacchiotti, Silvia

AU - Meazza, Cristina

AU - Zaffignani, Elena

AU - Marchianò, Alfonso

AU - Casanova, Michela

PY - 2007/11

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AB - We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

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KW - Low-dose cyclophosphamide

KW - Metronomic therapy

KW - Vinorelbine

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