Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

Andrea Ferrari; Federica Grosso; Silvia Stacchiotti; Cristina Meazza; Elena Zaffignani; Alfonso Marchianò; Michela Casanova

doi:10.1002/pbc.20682

Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

Andrea Ferrari, Federica Grosso, Silvia Stacchiotti, Cristina Meazza, Elena Zaffignani, Alfonso Marchianò, Michela Casanova

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

Original language	English
Pages (from-to)	864-866
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/pbc.20682
Publication status	Published - Nov 2007

Keywords

Desmoplastic small round cell tumor
Low-dose cyclophosphamide
Metronomic therapy
Vinorelbine

ASJC Scopus subject areas

Cancer Research
Pediatrics, Perinatology, and Child Health
Hematology

Access to Document

10.1002/pbc.20682

Cite this

@article{a29cf48f5f5646c0bcfb42d4746ea7f1,

title = "Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor",

abstract = "We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.",

keywords = "Desmoplastic small round cell tumor, Low-dose cyclophosphamide, Metronomic therapy, Vinorelbine",

author = "Andrea Ferrari and Federica Grosso and Silvia Stacchiotti and Cristina Meazza and Elena Zaffignani and Alfonso Marchian{\`o} and Michela Casanova",

year = "2007",

month = nov,

doi = "10.1002/pbc.20682",

language = "English",

volume = "49",

pages = "864--866",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

AU - Ferrari, Andrea

AU - Grosso, Federica

AU - Stacchiotti, Silvia

AU - Meazza, Cristina

AU - Zaffignani, Elena

AU - Marchianò, Alfonso

AU - Casanova, Michela

PY - 2007/11

Y1 - 2007/11

N2 - We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

AB - We report two cases of abdominal desmoplastic small round cell tumor (DSRCT) that showed a clinical response to the vinorelbine/low-dose cyclophosphamide combination that has been claimed to be effective for rhabdomyosarcoma. This observation may prompt further investigation into the activity of such a regimen in DSRCT patients with recurrent or refractory disease, with a view to a possible future role as maintenance therapy in controlling minimal residual disease in patients who achieve complete remission with intensive induction multimodality therapy.

KW - Desmoplastic small round cell tumor

KW - Low-dose cyclophosphamide

KW - Metronomic therapy

KW - Vinorelbine

UR - http://www.scopus.com/inward/record.url?scp=34948890470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34948890470&partnerID=8YFLogxK

U2 - 10.1002/pbc.20682

DO - 10.1002/pbc.20682

M3 - Article

C2 - 16302215

AN - SCOPUS:34948890470

VL - 49

SP - 864

EP - 866

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 6

ER -

Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this