Responsiveness in rheumatoid arthritis. A report from the OMERACT 11 ultrasound workshop

Annamaria Iagnocco, Esperanza Naredo, Richard Wakefield, George A W Bruyn, Paz Collado, Sandrine Jousse-Joulin, Stephanie Finzel, Sarah Ohrndorf, Andrea Delle Sedie, Marina Backhaus, Hilde Berner-Hammer, Frederique Gandjbakhch, Gurjit Kaeley, Damien Loeuille, Ingrid Moller, Lene Terslev, Philippe Aegerter, Sibel Aydin, Peter V. Balint, Emilio FilippucciPeter Mandl, Carlos Pineda, Johannes Roth, Silvia Magni-Manzoni, Niolay Tzaribachev, Wolfgang A. Schmidt, Philip G. Conaghan, Maria Antonietta D'Agostino

Research output: Contribution to journalArticle

Abstract

Objective. To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. Methods. The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. Results. The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. Conclusion. At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis. (First Release Nov 15 2013; J Rheumatol 2014;41:379-82; doi:10.3899/ jrheum.131084).

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalJournal of Rheumatology
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Arthritis
  • Omeract
  • Responsiveness
  • Rheumatoid
  • Ultrasound

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Responsiveness in rheumatoid arthritis. A report from the OMERACT 11 ultrasound workshop'. Together they form a unique fingerprint.

  • Cite this

    Iagnocco, A., Naredo, E., Wakefield, R., Bruyn, G. A. W., Collado, P., Jousse-Joulin, S., Finzel, S., Ohrndorf, S., Delle Sedie, A., Backhaus, M., Berner-Hammer, H., Gandjbakhch, F., Kaeley, G., Loeuille, D., Moller, I., Terslev, L., Aegerter, P., Aydin, S., Balint, P. V., ... D'Agostino, M. A. (2014). Responsiveness in rheumatoid arthritis. A report from the OMERACT 11 ultrasound workshop. Journal of Rheumatology, 41(2), 379-382. https://doi.org/10.3899/jrheum.131084