Abstract
Objective. To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. Methods. The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. Results. The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. Conclusion. At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis. (First Release Nov 15 2013; J Rheumatol 2014;41:379-82; doi:10.3899/ jrheum.131084).
| Original language | English |
|---|---|
| Pages (from-to) | 379-382 |
| Number of pages | 4 |
| Journal | Journal of Rheumatology |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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Keywords
- Arthritis
- Omeract
- Responsiveness
- Rheumatoid
- Ultrasound
ASJC Scopus subject areas
- Rheumatology
- Immunology
- Immunology and Allergy
Cite this
Responsiveness in rheumatoid arthritis. A report from the OMERACT 11 ultrasound workshop. / Iagnocco, Annamaria; Naredo, Esperanza; Wakefield, Richard; Bruyn, George A W; Collado, Paz; Jousse-Joulin, Sandrine; Finzel, Stephanie; Ohrndorf, Sarah; Delle Sedie, Andrea; Backhaus, Marina; Berner-Hammer, Hilde; Gandjbakhch, Frederique; Kaeley, Gurjit; Loeuille, Damien; Moller, Ingrid; Terslev, Lene; Aegerter, Philippe; Aydin, Sibel; Balint, Peter V.; Filippucci, Emilio; Mandl, Peter; Pineda, Carlos; Roth, Johannes; Magni-Manzoni, Silvia; Tzaribachev, Niolay; Schmidt, Wolfgang A.; Conaghan, Philip G.; D'Agostino, Maria Antonietta.
In: Journal of Rheumatology, Vol. 41, No. 2, 02.2014, p. 379-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Responsiveness in rheumatoid arthritis. A report from the OMERACT 11 ultrasound workshop
AU - Iagnocco, Annamaria
AU - Naredo, Esperanza
AU - Wakefield, Richard
AU - Bruyn, George A W
AU - Collado, Paz
AU - Jousse-Joulin, Sandrine
AU - Finzel, Stephanie
AU - Ohrndorf, Sarah
AU - Delle Sedie, Andrea
AU - Backhaus, Marina
AU - Berner-Hammer, Hilde
AU - Gandjbakhch, Frederique
AU - Kaeley, Gurjit
AU - Loeuille, Damien
AU - Moller, Ingrid
AU - Terslev, Lene
AU - Aegerter, Philippe
AU - Aydin, Sibel
AU - Balint, Peter V.
AU - Filippucci, Emilio
AU - Mandl, Peter
AU - Pineda, Carlos
AU - Roth, Johannes
AU - Magni-Manzoni, Silvia
AU - Tzaribachev, Niolay
AU - Schmidt, Wolfgang A.
AU - Conaghan, Philip G.
AU - D'Agostino, Maria Antonietta
PY - 2014/2
Y1 - 2014/2
N2 - Objective. To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. Methods. The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. Results. The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. Conclusion. At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis. (First Release Nov 15 2013; J Rheumatol 2014;41:379-82; doi:10.3899/ jrheum.131084).
AB - Objective. To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop. Methods. The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA. Results. The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing. Conclusion. At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis. (First Release Nov 15 2013; J Rheumatol 2014;41:379-82; doi:10.3899/ jrheum.131084).
KW - Arthritis
KW - Omeract
KW - Responsiveness
KW - Rheumatoid
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84893611910&partnerID=8YFLogxK
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U2 - 10.3899/jrheum.131084
DO - 10.3899/jrheum.131084
M3 - Article
VL - 41
SP - 379
EP - 382
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 2
ER -