Responsiveness of clinical measures in children with oligoarticular juvenile chronic arthritis

Nicolino Ruperto, Angelo Ravelli, Daniela Migliavacca, Stefania Viola, Angela Pistorio, Carolina Duarte, Alberto Martini

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective. To compare the relative responsiveness of outcome measures in children with oligoarticular course juvenile chronic arthritis (JCA). Methods. Twenty-six consecutive children with JCA and ≤ 4 joints involved were assessed at admission and after 3 months of followup. Outcome measures included physician and parent global assessments, functional ability as measured by the Childhood Health Assessment Questionnaire (CHAQ), articular variables, and laboratory indicators of systemic inflammation. Responsiveness was calculated with the standardized response median, the effect size, and the Guyatt method. Results. The physician global assessment of disease activity, the active joint count, the global articular severity score, and the number and score of swollen joints proved consistently more responsive with either responsiveness measure used. The parent global assessment of the child's well being, the scores of joints with pain/tenderness and limited range of motion, and the number of joints with limited range of motion showed intermediate responsiveness. The CHAQ, morning stiffness, and laboratory indicators of systemic inflammation were the least responsive measures. Conclusion. The subjective estimation of disease activity by the physician and the articular variables were the more responsive outcome measures in children with oligoarticular JCA. The assessment of functional ability as measured by the CHAQ showed a poor sensitivity to clinical change in this subset of patients with JCA.

Original languageEnglish
Pages (from-to)1827-1830
Number of pages4
JournalJournal of Rheumatology
Volume26
Issue number8
Publication statusPublished - 1999

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Juvenile Arthritis
Joints
Aptitude
Outcome Assessment (Health Care)
Articular Range of Motion
Physicians
Health
Inflammation
Arthralgia
Surveys and Questionnaires

Keywords

  • Juvenile chronic arthritis
  • Outcome measures
  • Responsiveness

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Responsiveness of clinical measures in children with oligoarticular juvenile chronic arthritis. / Ruperto, Nicolino; Ravelli, Angelo; Migliavacca, Daniela; Viola, Stefania; Pistorio, Angela; Duarte, Carolina; Martini, Alberto.

In: Journal of Rheumatology, Vol. 26, No. 8, 1999, p. 1827-1830.

Research output: Contribution to journalArticle

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AU - Pistorio, Angela

AU - Duarte, Carolina

AU - Martini, Alberto

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