Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: A longitudinal study

Karine Baumstarck, Helmut Butzkueven, Oscar Fernández, Peter Flachenecker, Sergio Stecchi, Egemen Idiman, Jean Pelletier, Mohamed Boucekine, Pascal Auquier

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Responsiveness, defined as the ability to detect a meaningful change, is a core psychometric property of an instrument measuring quality of life (QoL) rarely reported in multiple sclerosis (MS) studies.Objective: To assess the responsiveness of the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire to change in disability over 24 months, defined by change in the Expanded Disability Status Scale (EDSS) score.Methods: Patients with MS were enrolled into a multicenter, longitudinal observational study. QoL was assessed using both the MusiQoL and the 36-Item Short-Form (SF-36) instruments at baseline and every 6 months thereafter up to month 24; neurological assessments, including EDSS score, were performed at each evaluation.Results: The 24-month EDSS was available for 524 patients. In the 107 worsened patients, two specific dimensions of MusiQoL, the sentimental and sexual life and the relationships with health care system dimensions, and 'physical' scores of SF-36 showed responsiveness.Conclusions: Whereas specific dimensions of MusiQoL identified EDSS changes, the MusiQoL index did not detect disability changes in worsened MS patients in a 24-month observational study. Future responsiveness validation studies should include longer follow-up and more representative samples.

Original languageEnglish
Article number127
JournalHealth and Quality of Life Outcomes
Volume11
Issue number1
DOIs
Publication statusPublished - Jul 29 2013

Keywords

  • Longitudinal studies
  • Multiple sclerosis
  • MusiQoL
  • Outcome research
  • Quality of life
  • Responsiveness
  • SF-36

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

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