Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis

Eliana Roveda, Eleonora Bruno, Letizia Galasso, Antonino Mulè, Lucia Castelli, Anna Villarini, Andrea Caumo, Fabio Esposito, Angela Montaruli, Patrizia Pasanisi

Research output: Contribution to journalArticle

Abstract

Rest-activity circadian rhythm (RAR) is a marker of the circadian timing system. Particular attention has been given to RAR characteristics in cancer diseases. Specifically, alterations of RAR parameters have been found, at different stages of clinical pathway, in breast cancer (BC) patients. No studies to date have analyzed RAR alterations in breast cancer survivors several years after the diagnosis. The aim of this study was to determine RAR by actigraphy in a population of BC survivors at 5 years after the primary diagnosis, and to compare their RAR characteristics with healthy controls. The study sample was 28 women: 15 BC survivors at 5 years from the primary diagnosis (BC-group) and 13 healthy controls (Ctrl-group), matched for age and body mass index. All participants have been monitored for 7 days by actigraphy to evaluate RAR. A statistically significant circadian rhythm (T = 24) was found in all 28 subjects (p < .001). The group analysis revealed a significant RAR both in BC- and Ctrl-group (p < .001). The acrophase was not different between the BC- and Ctrl-group (15:09 vs. 15:01 hr:min in BC- and Ctrl-group, respectively). In contrast, the MESOR (Midline Estimating Statistic of Rhythm) and the amplitude were lower in the BC-group with respect to the Ctrl-group. Indeed, the MESOR was 192.0 vs. 276.4 activity counts in BC- and Ctrl-group, respectively (p < .001), while the amplitude was 167.0 vs. 222.6 activity counts in BC- and Ctrl-group, respectively (p < .001). These results provide the first experimental evidence of alterations in RAR parameters in BC survivors at 5 years after the primary diagnosis. Larger studies with a prospective design are needed to assess the role of RAR in the quality of life and prognosis in BC survivors.

Original languageEnglish
Pages (from-to)1156-1165
Number of pages10
JournalChronobiology International
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 3 2019

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Circadian Rhythm
Survivors
Breast Neoplasms
Actigraphy
Circadian Clocks
Critical Pathways
Body Mass Index
Quality of Life

Keywords

  • actigraphy
  • activity level
  • Breast cancer
  • rest-activity circadian rhythm

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis. / Roveda, Eliana; Bruno, Eleonora; Galasso, Letizia; Mulè, Antonino; Castelli, Lucia; Villarini, Anna; Caumo, Andrea; Esposito, Fabio; Montaruli, Angela; Pasanisi, Patrizia.

In: Chronobiology International, Vol. 36, No. 8, 03.08.2019, p. 1156-1165.

Research output: Contribution to journalArticle

Roveda, E, Bruno, E, Galasso, L, Mulè, A, Castelli, L, Villarini, A, Caumo, A, Esposito, F, Montaruli, A & Pasanisi, P 2019, 'Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis', Chronobiology International, vol. 36, no. 8, pp. 1156-1165. https://doi.org/10.1080/07420528.2019.1621330
Roveda, Eliana ; Bruno, Eleonora ; Galasso, Letizia ; Mulè, Antonino ; Castelli, Lucia ; Villarini, Anna ; Caumo, Andrea ; Esposito, Fabio ; Montaruli, Angela ; Pasanisi, Patrizia. / Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis. In: Chronobiology International. 2019 ; Vol. 36, No. 8. pp. 1156-1165.
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