Resting cardiac energy metabolism is inversely associated with heart rate in healthy young adult men

Gabriele Fragasso, Francesco De Cobelli, Roberto Spoladore, Antonio Esposito, Anna Salerno, Giliola Calori, Claudia Montanaro, Francesco Maranta, Guido Lattuada, Alberto Margonato, Alessandro Del Maschio, Gianluca Perseghin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: 31-Phosphorus-magnetic resonance spectroscopy may provide pathophysiological insights into the high-energy phosphate metabolism of the myocardium as measured by phosphocreatine to adenosine triphosphate (PCr/ATP) ratio. Aim of the present study was to determine in vivo the relation between cardiac PCr/ATP ratio and heart rate in normal male subjects. Methods: One hundred twelve apparently healthy, young male individuals (age 34 ± 10 years) were prospectively evaluated. They underwent cardiac cine magnetic resonance imaging to assess left ventricular (LV) function and morphology and 3D-ISIS 31P-magnetic resonance spectroscopy of the LV to assess the PCr/ATP ratio (a recognized in vivo marker of myocardial energy metabolism). Data were analyzed after segregation by tertiles of the resting PCr/ATP ratio. Results: A significant inverse association between PCr/ATP ratios and resting heart rate was observed (Spearman ρ: r=-0.37; P

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalAmerican Heart Journal
Volume162
Issue number1
DOIs
Publication statusPublished - Jul 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Resting cardiac energy metabolism is inversely associated with heart rate in healthy young adult men'. Together they form a unique fingerprint.

Cite this