TY - JOUR
T1 - Resting cardiac energy metabolism is inversely associated with heart rate in healthy young adult men
AU - Fragasso, Gabriele
AU - De Cobelli, Francesco
AU - Spoladore, Roberto
AU - Esposito, Antonio
AU - Salerno, Anna
AU - Calori, Giliola
AU - Montanaro, Claudia
AU - Maranta, Francesco
AU - Lattuada, Guido
AU - Margonato, Alberto
AU - Del Maschio, Alessandro
AU - Perseghin, Gianluca
PY - 2011/7
Y1 - 2011/7
N2 - Background: 31-Phosphorus-magnetic resonance spectroscopy may provide pathophysiological insights into the high-energy phosphate metabolism of the myocardium as measured by phosphocreatine to adenosine triphosphate (PCr/ATP) ratio. Aim of the present study was to determine in vivo the relation between cardiac PCr/ATP ratio and heart rate in normal male subjects. Methods: One hundred twelve apparently healthy, young male individuals (age 34 ± 10 years) were prospectively evaluated. They underwent cardiac cine magnetic resonance imaging to assess left ventricular (LV) function and morphology and 3D-ISIS
31P-magnetic resonance spectroscopy of the LV to assess the PCr/ATP ratio (a recognized in vivo marker of myocardial energy metabolism). Data were analyzed after segregation by tertiles of the resting PCr/ATP ratio. Results: A significant inverse association between PCr/ATP ratios and resting heart rate was observed (Spearman ρ: r=-0.37; P
AB - Background: 31-Phosphorus-magnetic resonance spectroscopy may provide pathophysiological insights into the high-energy phosphate metabolism of the myocardium as measured by phosphocreatine to adenosine triphosphate (PCr/ATP) ratio. Aim of the present study was to determine in vivo the relation between cardiac PCr/ATP ratio and heart rate in normal male subjects. Methods: One hundred twelve apparently healthy, young male individuals (age 34 ± 10 years) were prospectively evaluated. They underwent cardiac cine magnetic resonance imaging to assess left ventricular (LV) function and morphology and 3D-ISIS
31P-magnetic resonance spectroscopy of the LV to assess the PCr/ATP ratio (a recognized in vivo marker of myocardial energy metabolism). Data were analyzed after segregation by tertiles of the resting PCr/ATP ratio. Results: A significant inverse association between PCr/ATP ratios and resting heart rate was observed (Spearman ρ: r=-0.37; P
UR - http://www.scopus.com/inward/record.url?scp=79960152080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960152080&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2011.04.012
DO - 10.1016/j.ahj.2011.04.012
M3 - Article
C2 - 21742100
AN - SCOPUS:79960152080
VL - 162
SP - 136
EP - 141
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -