Resting energy expenditure in young patients with cystic fibrosis receiving antibiotic therapy for acute respiratory exacerbations

M. Castro, A. Diamanti, M. Gambarara, S. Bella, V. Lucidi, B. Papadatou, F. Ferretti, P. Rosati, E. Rupi

Research output: Contribution to journalArticle


Background: Patients with cystic fibrosis commonly have severe malnutrition and growth retardation. Among possible causes of these manifestations are low caloric intake, loss of nutrients and increased resting energy expenditure. This study was designed to assess the influence of antibiotic therapy for infectious exacerbations on resting energy expenditure in young patients with cystic fibrosis. Methods: We studied 17 patients with cystic fibrosis (mean age, 13.6 years). All were hospitalized to receive intravenous antibiotic therapy (mean duration, 2 weeks) for acute respiratory exacerbations. At the beginning of therapy and after it ended, all patients underwent blood chemical tests, anthropometrical measures, determination of body composition by bioelectrical impedance, spirometry, and indirect calorimetry. Results: Antibiotic therapy led to a significant improvement in biochemical, spirometric variables and in estimated calorimetry measurements expressed in relation to fat-free mass. These findings suggest that infective exacerbations are among the causes of increased resting energy expenditure in young patients with cystic fibrosis. Conclusions: Indirect calorimetry may prove useful in the diagnosis of infective e xacerbations and in monitoring the effect of antibiotic therapy in patients with cystic fibrosis.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalClinical Nutrition
Issue number2
Publication statusPublished - 2002



  • Cystic fibrosis
  • Indirect calorimetry
  • Resting energy expenditure

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)

Cite this