Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project

Silvia Morbelli, Alex Drzezga, Robert Perneczky, Giovanni B. Frisoni, Anna Caroli, Bart N M van Berckel, Rik Ossenkoppele, Eric Guedj, Mira Didic, Andrea Brugnolo, Gianmario Sambuceti, Marco Pagani, Eric Salmon, Flavio Nobili

Research output: Contribution to journalArticlepeer-review


We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration).

Original languageEnglish
Pages (from-to)2533-2550
Number of pages18
JournalNeurobiology of Aging
Issue number11
Publication statusPublished - Nov 2012


  • Functional connectivity
  • Positron emission tomography
  • Prodromal Alzheimer's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology


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