Resting-state brain networks: Literature review and clinical applications

Cristina Rosazza, Ludovico Minati

Research output: Contribution to journalArticlepeer-review


This review focuses on resting-state functional connectivity, a functional MRI technique which allows the study of spontaneous brain activity generated under resting conditions. This approach is useful to explore the brain's functional organization and to examine if it is altered in neurological or psychiatric diseases. Resting-state functional connectivity has revealed a number of networks which are consistently found in healthy subjects and represent specific patterns of synchronous activity. In this review, we examine the behavioral, physiological and neurological evidences relevant to this coherent brain activity and, in particular, to each network. The investigation of functional connectivity appears promising from a clinical perspective, considering the amount of evidence regarding the importance of spontaneous activity and that resting-state paradigms are inherently simple to implement. We also discuss some examples of existing clinical applications, such as in Alzheimer's disease, and emerging possibilities such as in pre-operative mapping and disorders of consciousness.

Original languageEnglish
Pages (from-to)773-785
Number of pages13
JournalNeurological Sciences
Issue number5
Publication statusPublished - Oct 2011


  • Clinical applications
  • Cognitive correlates
  • Coherence
  • Functional connectivity
  • Resting state
  • Spontaneous brain activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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