Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease

Cristina Sánchez-Castañeda, Francesco de Pasquale, Chiara Falletta Caravasso, Massimo Marano, Sabrina Maffi, Simone Migliore, Umberto Sabatini, Ferdinando Squitieri

Research output: Contribution to journalArticlepeer-review


AIMS: To analyze brain functional connectivity in the somatomotor and default-mode networks (DMNs) of patients with Huntington disease (HD), its relationship with gray matter (GM) volume loss, and functional changes after pridopidine treatment.

METHODS: Ten patients and ten untreated controls underwent T1-weighted imaging and resting-state functional magnetic resonance imaging (fMRI); four patients were also assessed after 3 months of pridopidine treatment (90 mg/d). The seed-based functional connectivity patterns from the posterior cingulate cortex and the supplementary motor area (SMA), considered cortical hubs of the DMN and somatomotor networks, respectively, were computed. FMRIB Software Library voxel-based morphometry measured GM volume.

RESULTS: Patients had GM volume decrease in all cortical and subcortical areas of the somatomotor network with preservation of the SMA, and increased somatomotor and DMN connectivity. In DMN structures, functional connectivity impairment preceded volume loss. Pridopidine reduced the intensity of these aberrant connections.

CONCLUSION: The abnormal connectivity of the somatomotor and DMN observed in HD patients may represent an early dysfunction marker, as it preceded volume loss in DMN. Pridopidine reduced connectivity of these networks in all four treated patients, suggesting that connectivity is sensitive to treatment response.

Original languageEnglish
Pages (from-to)488-497
Number of pages10
JournalCNS Neuroscience and Therapeutics
Issue number6
Publication statusPublished - Jun 2017


  • Journal Article


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