Resting state connectivity between default mode network and insula encodes acute migraine headache.

Gianluca Coppola, Antonio Di Renzo, E Tinelli, Cherubino Di Lorenzo, M Scapeccia, Vincenzo Parisi, M Serrao, M Evangelista, Anna Ambrosini, Claudio Colonnese, Jean Schoenen, Francesco Pierelli

Research output: Contribution to journalArticle

Abstract

Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pai
Original languageEnglish
Article numberdoi: 10.1177/0333102417715230. [
JournalCephalalgia
Publication statusPublished - Jan 1 2017

Fingerprint

Migraine Disorders
Prefrontal Cortex
Gyrus Cinguli
Pain
Headache
Seeds
Healthy Volunteers
Magnetic Resonance Imaging
Migraine without Aura
Parietal Lobe
Somatoform Disorders
Visual Analog Scale
Chronic Pain
Head

Cite this

Coppola, G., Di Renzo, A., Tinelli, E., Di Lorenzo, C., Scapeccia, M., Parisi, V., ... Pierelli, F. (2017). Resting state connectivity between default mode network and insula encodes acute migraine headache. Cephalalgia, [doi: 10.1177/0333102417715230. [].

Resting state connectivity between default mode network and insula encodes acute migraine headache. / Coppola, Gianluca; Di Renzo, Antonio; Tinelli, E; Di Lorenzo, Cherubino; Scapeccia, M; Parisi, Vincenzo; Serrao, M; Evangelista, M; Ambrosini, Anna; Colonnese, Claudio; Schoenen, Jean; Pierelli, Francesco.

In: Cephalalgia, 01.01.2017.

Research output: Contribution to journalArticle

Coppola, G, Di Renzo, A, Tinelli, E, Di Lorenzo, C, Scapeccia, M, Parisi, V, Serrao, M, Evangelista, M, Ambrosini, A, Colonnese, C, Schoenen, J & Pierelli, F 2017, 'Resting state connectivity between default mode network and insula encodes acute migraine headache.', Cephalalgia.
Coppola G, Di Renzo A, Tinelli E, Di Lorenzo C, Scapeccia M, Parisi V et al. Resting state connectivity between default mode network and insula encodes acute migraine headache. Cephalalgia. 2017 Jan 1. doi: 10.1177/0333102417715230. [.
Coppola, Gianluca ; Di Renzo, Antonio ; Tinelli, E ; Di Lorenzo, Cherubino ; Scapeccia, M ; Parisi, Vincenzo ; Serrao, M ; Evangelista, M ; Ambrosini, Anna ; Colonnese, Claudio ; Schoenen, Jean ; Pierelli, Francesco. / Resting state connectivity between default mode network and insula encodes acute migraine headache. In: Cephalalgia. 2017.
@article{72178e3ee2d24a34a6ee9bcf617edd77,
title = "Resting state connectivity between default mode network and insula encodes acute migraine headache.",
abstract = "Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pai",
author = "Gianluca Coppola and {Di Renzo}, Antonio and E Tinelli and {Di Lorenzo}, Cherubino and M Scapeccia and Vincenzo Parisi and M Serrao and M Evangelista and Anna Ambrosini and Claudio Colonnese and Jean Schoenen and Francesco Pierelli",
year = "2017",
month = "1",
day = "1",
language = "English",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Resting state connectivity between default mode network and insula encodes acute migraine headache.

AU - Coppola, Gianluca

AU - Di Renzo, Antonio

AU - Tinelli, E

AU - Di Lorenzo, Cherubino

AU - Scapeccia, M

AU - Parisi, Vincenzo

AU - Serrao, M

AU - Evangelista, M

AU - Ambrosini, Anna

AU - Colonnese, Claudio

AU - Schoenen, Jean

AU - Pierelli, Francesco

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pai

AB - Background Previous functional MRI studies have revealed that ongoing clinical pain in different chronic pain syndromes is directly correlated to the connectivity strength of the resting default mode network (DMN) with the insula. Here, we investigated seed-based resting state DMN-insula connectivity during acute migraine headaches. Methods Thirteen migraine without aura patients (MI) underwent 3 T MRI scans during the initial six hours of a spontaneous migraine attack, and were compared to a group of 19 healthy volunteers (HV). We evaluated headache intensity with a visual analogue scale and collected seed-based MRI resting state data in the four core regions of the DMN: Medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and left and right inferior parietal lobules (IPLs), as well as in bilateral insula. Results Compared to HV, MI patients showed stronger functional connectivity between MPFC and PCC, and between MPFC and bilateral insula. During migraine attacks, the strength of MPFC-to-insula connectivity was negatively correlated with pain intensity. Conclusion We show that greater subjective intensity of pain during a migraine attack is associated with proportionally weaker DMN-insula connectivity. This is at variance with other chronic extra-cephalic pain disorders where the opposite was found, and may thus be a hallmark of acute migraine head pai

M3 - Article

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

M1 - doi: 10.1177/0333102417715230. [

ER -