TY - JOUR
T1 - Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with alzheimer's disease
T2 - An italian multicenter study
AU - Babiloni, Claudio
AU - Lizio, Roberta
AU - Carducci, Filippo
AU - Vecchio, Fabrizio
AU - Redolfi, Alberto
AU - Marino, Silvia
AU - Tedeschi, Gioacchino
AU - Montella, Patrizia
AU - Guizzaro, Antonio
AU - Esposito, Fabrizio
AU - Bozzao, Alessandro
AU - Giubilei, Franco
AU - Orzi, Francesco
AU - Quattrocchi, Carlo C.
AU - Soricelli, Andrea
AU - Salvatore, Elena
AU - Baglieri, Annalisa
AU - Bramanti, Placido
AU - Cavedo, Enrica
AU - Ferri, Raffaele
AU - Cosentino, Filomena
AU - Ferrara, Michelangelo
AU - Mundi, Ciro
AU - Grilli, Gianpaolo
AU - Pugliese, Silvia
AU - Gerardi, Gianluca
AU - Parisi, Laura
AU - Vernieri, Fabrizio
AU - Triggiani, Antonio I.
AU - Pedersen, Jan T.
AU - Hrdemark, Hans Göran
AU - Rossini, Paolo M.
AU - Frisoni, Giovanni B.
PY - 2011
Y1 - 2011
N2 - Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI-(people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI-group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD-group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD-group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
AB - Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI-(people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI-group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD-group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD-group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
KW - Alzheimer's disease
KW - Alzheimer's disease neuroimaging initiative
KW - amnesic mild c cognitive impairment
KW - electroencephalographic rhythms
KW - low resolution brain electromagnetic tomography
KW - magnetic resonance imaging
KW - resting state
KW - white matter vascular lesion
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U2 - 10.3233/JAD-2011-101710
DO - 10.3233/JAD-2011-101710
M3 - Article
C2 - 21673406
AN - SCOPUS:80052789069
VL - 26
SP - 331
EP - 346
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -