Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with alzheimer's disease: An italian multicenter study

Claudio Babiloni, Roberta Lizio, Filippo Carducci, Fabrizio Vecchio, Alberto Redolfi, Silvia Marino, Gioacchino Tedeschi, Patrizia Montella, Antonio Guizzaro, Fabrizio Esposito, Alessandro Bozzao, Franco Giubilei, Francesco Orzi, Carlo C. Quattrocchi, Andrea Soricelli, Elena Salvatore, Annalisa Baglieri, Placido Bramanti, Enrica Cavedo, Raffaele FerriFilomena Cosentino, Michelangelo Ferrara, Ciro Mundi, Gianpaolo Grilli, Silvia Pugliese, Gianluca Gerardi, Laura Parisi, Fabrizio Vernieri, Antonio I. Triggiani, Jan T. Pedersen, Hans Göran Hrdemark, Paolo M. Rossini, Giovanni B. Frisoni

Research output: Contribution to journalArticle

Abstract

Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI-(people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI-group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD-group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD-group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.

Original languageEnglish
Pages (from-to)331-346
Number of pages16
JournalJournal of Alzheimer's Disease
Volume26
Issue number2
DOIs
Publication statusPublished - 2011

Keywords

  • Alzheimer's disease
  • Alzheimer's disease neuroimaging initiative
  • amnesic mild c cognitive impairment
  • electroencephalographic rhythms
  • low resolution brain electromagnetic tomography
  • magnetic resonance imaging
  • resting state
  • white matter vascular lesion

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Fingerprint Dive into the research topics of 'Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with alzheimer's disease: An italian multicenter study'. Together they form a unique fingerprint.

  • Cite this