TY - JOUR
T1 - Resting state cortical rhythms in mild cognitive impairment and Alzheimer's disease
T2 - Electroencephalographic evidence
AU - Babiloni, Claudio
AU - Vecchio, Fabrizio
AU - Lizio, Roberta
AU - Ferri, Raffaele
AU - Rodriguez, Guido
AU - Marzano, Nicola
AU - Frisoni, Giovanni B.
AU - Rossini, Paolo M.
PY - 2011
Y1 - 2011
N2 - Physiological brain aging is characterized by a combination of synaptic pruning, loss of cortico-cortical connections and neuronal apoptosis that provoke age-dependent decline of cognitive functions. Neural/synaptic redundancy and plastic remodeling of brain networking, also secondary to mental and physical training, promotes maintenance of brain activity in healthy elderly for everyday life and fully productive affective and intellectual capabilities. Unfortunately, in pathological situations, aging triggers neurodegenerative processes that impact on cognition, like Alzheimer's disease (AD). Oscillatory electromagnetic brain activity is a hallmark of neuronal network function in various brain regions. Modern neurophysiological techniques including digital electroencephalography (EEG) allow non-invasive analysis of cortico-cortical connectivity and neuronal synchronization of firing, and coherence of brain rhythmic oscillations at various frequencies. The present review of field EEG literature suggests that discrimination between physiological and pathological brain aging clearly emerges at the group level, with some promising result on the informative value of EEG markers at the individual level. Integrated approaches utilizing neurophysiological techniques together with biological markers and structural and functional imaging are promising for large-scale, low-cost, widely available on the territory and non-invasive screening of at-risk populations.
AB - Physiological brain aging is characterized by a combination of synaptic pruning, loss of cortico-cortical connections and neuronal apoptosis that provoke age-dependent decline of cognitive functions. Neural/synaptic redundancy and plastic remodeling of brain networking, also secondary to mental and physical training, promotes maintenance of brain activity in healthy elderly for everyday life and fully productive affective and intellectual capabilities. Unfortunately, in pathological situations, aging triggers neurodegenerative processes that impact on cognition, like Alzheimer's disease (AD). Oscillatory electromagnetic brain activity is a hallmark of neuronal network function in various brain regions. Modern neurophysiological techniques including digital electroencephalography (EEG) allow non-invasive analysis of cortico-cortical connectivity and neuronal synchronization of firing, and coherence of brain rhythmic oscillations at various frequencies. The present review of field EEG literature suggests that discrimination between physiological and pathological brain aging clearly emerges at the group level, with some promising result on the informative value of EEG markers at the individual level. Integrated approaches utilizing neurophysiological techniques together with biological markers and structural and functional imaging are promising for large-scale, low-cost, widely available on the territory and non-invasive screening of at-risk populations.
KW - Alzheimer's disease
KW - Consciousness
KW - electroencephalography (EEG)
KW - persistent vegetative state
UR - http://www.scopus.com/inward/record.url?scp=84865439186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865439186&partnerID=8YFLogxK
U2 - 10.3233/978-1-60750-793-2-391
DO - 10.3233/978-1-60750-793-2-391
M3 - Article
AN - SCOPUS:84865439186
VL - 2
SP - 391
EP - 404
JO - Advances in Alzheimer's Disease
JF - Advances in Alzheimer's Disease
SN - 2210-5727
ER -