Abstract
Original language | English |
---|---|
Pages (from-to) | 259-270 |
Number of pages | 12 |
Journal | Int. J. Psychophysiol. |
Volume | 158 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Alzheimer's disease dementia (ADD)
- Delta rhythms
- Exact low resolution brain electromagnetic source tomography (eLORETA)
- Resting state electroencephalographic (rsEEG) rhythms
- antihypertensive agent
- benzodiazepine derivative
- donepezil
- galantamine
- rivastigmine
- aged
- alpha rhythm
- Alzheimer disease
- arousal
- Article
- brain cortex
- clinical assessment
- comparative study
- controlled study
- correlation analysis
- current density
- delta rhythm
- dementia
- electroencephalography
- female
- Fourier transform
- health education
- human
- major clinical study
- male
- resting state network
- wakefulness
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Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia. / Babiloni, C.; Ferri, R.; Noce, G.; Lizio, R.; Lopez, S.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Famà, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Cipollini, V.; Marizzoni, M.; Güntekin, B.; Aktürk, T.; Hanoğlu, L.; Yener, G.; Emek-Savaş, D.D.; Stocchi, F.; Vacca, L.; Frisoni, G.B.; Del Percio, C.
In: Int. J. Psychophysiol., Vol. 158, 2020, p. 259-270.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
AU - Babiloni, C.
AU - Ferri, R.
AU - Noce, G.
AU - Lizio, R.
AU - Lopez, S.
AU - Soricelli, A.
AU - Nobili, F.
AU - Arnaldi, D.
AU - Famà, F.
AU - Orzi, F.
AU - Buttinelli, C.
AU - Giubilei, F.
AU - Cipollini, V.
AU - Marizzoni, M.
AU - Güntekin, B.
AU - Aktürk, T.
AU - Hanoğlu, L.
AU - Yener, G.
AU - Emek-Savaş, D.D.
AU - Stocchi, F.
AU - Vacca, L.
AU - Frisoni, G.B.
AU - Del Percio, C.
N1 - Cited By :1 Export Date: 23 February 2021 CODEN: IJPSE Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it Chemicals/CAS: donepezil, 120011-70-3, 120014-06-4, 142057-77-0; galantamine, 1953-04-4, 357-70-0; rivastigmine, 129101-54-8, 123441-03-2 Funding details: Horizon 2020 Framework Programme, H2020 Funding text 1: In this study, the electroencephalographic data analysis was partially supported by the funds of “Ricerca Corrente” attributed by Italian Ministry of Health to the IRCCS SDN of Naples, IRCCS OASI of Troina (Enna), and IRCCS San Raffaele Pisana of Rome (Italy). The research activities of the Unit of Sapienza University of Rome were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title “BBDiag” ( http://bbdiag-itn-etn.eu ) and the H2020-TWINN-2015 project with the short title “SynaNet” ( https://www.synanet2020.com ). 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PY - 2020
Y1 - 2020
N2 - Extending Başar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD). Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (<4 Hz) and alpha1 (8–10.5 Hz) bands were used for the main analysis, while alpha2 (10.5–13 Hz), theta (4–8 Hz), beta1 (13–20 Hz), beta2 (20–35 Hz), and gamma (35–40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1–2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions. These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism. © 2020 Elsevier B.V.
AB - Extending Başar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD). Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (<4 Hz) and alpha1 (8–10.5 Hz) bands were used for the main analysis, while alpha2 (10.5–13 Hz), theta (4–8 Hz), beta1 (13–20 Hz), beta2 (20–35 Hz), and gamma (35–40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1–2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions. These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism. © 2020 Elsevier B.V.
KW - Alzheimer's disease dementia (ADD)
KW - Delta rhythms
KW - Exact low resolution brain electromagnetic source tomography (eLORETA)
KW - Resting state electroencephalographic (rsEEG) rhythms
KW - antihypertensive agent
KW - benzodiazepine derivative
KW - donepezil
KW - galantamine
KW - rivastigmine
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - arousal
KW - Article
KW - brain cortex
KW - clinical assessment
KW - comparative study
KW - controlled study
KW - correlation analysis
KW - current density
KW - delta rhythm
KW - dementia
KW - electroencephalography
KW - female
KW - Fourier transform
KW - health education
KW - human
KW - major clinical study
KW - male
KW - resting state network
KW - wakefulness
U2 - 10.1016/j.ijpsycho.2020.08.012
DO - 10.1016/j.ijpsycho.2020.08.012
M3 - Article
VL - 158
SP - 259
EP - 270
JO - Int. J. Psychophysiol.
JF - Int. J. Psychophysiol.
SN - 0167-8760
ER -