Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia

C. Babiloni, R. Ferri, G. Noce, R. Lizio, S. Lopez, A. Soricelli, F. Nobili, D. Arnaldi, F. Famà, F. Orzi, C. Buttinelli, F. Giubilei, V. Cipollini, M. Marizzoni, B. Güntekin, T. Aktürk, L. Hanoğlu, G. Yener, D.D. Emek-Savaş, F. StocchiL. Vacca, G.B. Frisoni, C. Del Percio

Research output: Contribution to journalArticlepeer-review

Abstract

Extending Başar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD). Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (<4 Hz) and alpha1 (8–10.5 Hz) bands were used for the main analysis, while alpha2 (10.5–13 Hz), theta (4–8 Hz), beta1 (13–20 Hz), beta2 (20–35 Hz), and gamma (35–40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1–2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions. These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism. © 2020 Elsevier B.V.
Original languageEnglish
Pages (from-to)259-270
Number of pages12
JournalInt. J. Psychophysiol.
Volume158
DOIs
Publication statusPublished - 2020

Keywords

  • Alzheimer's disease dementia (ADD)
  • Delta rhythms
  • Exact low resolution brain electromagnetic source tomography (eLORETA)
  • Resting state electroencephalographic (rsEEG) rhythms
  • antihypertensive agent
  • benzodiazepine derivative
  • donepezil
  • galantamine
  • rivastigmine
  • aged
  • alpha rhythm
  • Alzheimer disease
  • arousal
  • Article
  • brain cortex
  • clinical assessment
  • comparative study
  • controlled study
  • correlation analysis
  • current density
  • delta rhythm
  • dementia
  • electroencephalography
  • female
  • Fourier transform
  • health education
  • human
  • major clinical study
  • male
  • resting state network
  • wakefulness

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