Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome: An eeg study

Claudio Babiloni, Francesca Pistoia, Marco Sarà, Fabrizio Vecchio, Paola Buffo, Massimiliano Conson, Paolo Onorati, Giorgio Albertini, Paolo Maria Rossini

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.

Original languageEnglish
Pages (from-to)1816-1824
Number of pages9
JournalClinical Neurophysiology
Volume121
Issue number11
DOIs
Publication statusPublished - Nov 2010

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Quadriplegia
Brain Stem
Delta Rhythm
Cortical Synchronization
Alpha Rhythm
Electric Power Supplies
Occipital Lobe
Parietal Lobe
Electromagnetic Phenomena
Temporal Lobe
Eye Movements
Paralysis
Cerebral Cortex
Tomography

Keywords

  • Human cerebral cortex
  • Locked-in syndrome (LIS)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Motor imagery
  • Resting state eyes-closed electroencephalography (EEG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems
  • Medicine(all)

Cite this

Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome : An eeg study. / Babiloni, Claudio; Pistoia, Francesca; Sarà, Marco; Vecchio, Fabrizio; Buffo, Paola; Conson, Massimiliano; Onorati, Paolo; Albertini, Giorgio; Rossini, Paolo Maria.

In: Clinical Neurophysiology, Vol. 121, No. 11, 11.2010, p. 1816-1824.

Research output: Contribution to journalArticle

Babiloni, C, Pistoia, F, Sarà, M, Vecchio, F, Buffo, P, Conson, M, Onorati, P, Albertini, G & Rossini, PM 2010, 'Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome: An eeg study', Clinical Neurophysiology, vol. 121, no. 11, pp. 1816-1824. https://doi.org/10.1016/j.clinph.2010.04.027
Babiloni, Claudio ; Pistoia, Francesca ; Sarà, Marco ; Vecchio, Fabrizio ; Buffo, Paola ; Conson, Massimiliano ; Onorati, Paolo ; Albertini, Giorgio ; Rossini, Paolo Maria. / Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome : An eeg study. In: Clinical Neurophysiology. 2010 ; Vol. 121, No. 11. pp. 1816-1824.
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abstract = "Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.",
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