Abstract
Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.
| Original language | English |
|---|---|
| Pages (from-to) | 1816-1824 |
| Number of pages | 9 |
| Journal | Clinical Neurophysiology |
| Volume | 121 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2010 |
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Keywords
- Human cerebral cortex
- Locked-in syndrome (LIS)
- Low-resolution brain electromagnetic source tomography (LORETA)
- Motor imagery
- Resting state eyes-closed electroencephalography (EEG)
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Sensory Systems
- Medicine(all)
Cite this
Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome : An eeg study. / Babiloni, Claudio; Pistoia, Francesca; Sarà, Marco; Vecchio, Fabrizio; Buffo, Paola; Conson, Massimiliano; Onorati, Paolo; Albertini, Giorgio; Rossini, Paolo Maria.
In: Clinical Neurophysiology, Vol. 121, No. 11, 11.2010, p. 1816-1824.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Resting state eyes-closed cortical rhythms in patients with locked-in-syndrome
T2 - An eeg study
AU - Babiloni, Claudio
AU - Pistoia, Francesca
AU - Sarà, Marco
AU - Vecchio, Fabrizio
AU - Buffo, Paola
AU - Conson, Massimiliano
AU - Onorati, Paolo
AU - Albertini, Giorgio
AU - Rossini, Paolo Maria
PY - 2010/11
Y1 - 2010/11
N2 - Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.
AB - Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.
KW - Human cerebral cortex
KW - Locked-in syndrome (LIS)
KW - Low-resolution brain electromagnetic source tomography (LORETA)
KW - Motor imagery
KW - Resting state eyes-closed electroencephalography (EEG)
UR - http://www.scopus.com/inward/record.url?scp=77956920342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956920342&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2010.04.027
DO - 10.1016/j.clinph.2010.04.027
M3 - Article
C2 - 20541461
AN - SCOPUS:77956920342
VL - 121
SP - 1816
EP - 1824
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -