Abstract
Objective: Locked-in syndrome (LIS) is a state of complete paralysis, except for ocular movements, which results from ventral brainstem lesions. Patients typically are fully conscious. Here we tested the hypothesis that electroencephalographic (EEG) rhythms are abnormal in LIS patients, possibly due to an impaired neural synchronization between brainstem and cerebral cortex. Methods: Resting state eyes-closed EEG data were recorded in 13 LIS subjects and 15 cognitively normal control subjects. With reference to the individual alpha frequency (IAF), the bands of interest were delta (IAF-8 to IAF-6. Hz), theta (IAF-6 to IAF-4. Hz), alpha 1 (IAF-4 to IAF-2. Hz), alpha 2 (IAF-2 to IAF. Hz), and alpha 3 (IAF to IAF. +. 2. Hz). Furthermore, beta 1 (13-20. Hz) and beta 2 (20-30. Hz) bands were also considered. Cortical EEG sources were estimated by low-resolution electromagnetic tomography (LORETA). Results: The power of alpha 2 and alpha 3 sources in all regions was lower in patients with LIS compared to controls. The power of delta sources in central, parietal, occipital and temporal regions was higher in patients with LIS compared to controls. Conclusions: These results suggest that cortical sources of resting state eyes-closed alpha and delta rhythms are abnormal in LIS patients. Significance: LIS is accompanied by a functional impairment of cortical neuronal synchronization mechanisms in the resting state condition.
Original language | English |
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Pages (from-to) | 1816-1824 |
Number of pages | 9 |
Journal | Clinical Neurophysiology |
Volume | 121 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2010 |
Keywords
- Human cerebral cortex
- Locked-in syndrome (LIS)
- Low-resolution brain electromagnetic source tomography (LORETA)
- Motor imagery
- Resting state eyes-closed electroencephalography (EEG)
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Sensory Systems
- Medicine(all)