Resting-State Functional Magnetic Resonance Imaging for Brain Tumor Surgical Planning: Feasibility in Clinical Setting

Gianvincenzo Sparacia, Giuseppe Parla, Roberto Cannella, Alessandro Perri, Vincenzina Lo Re, Giuseppe Mamone, Roberto Miraglia, Fabio Torregrossa, Giovanni Grasso

Research output: Contribution to journalArticle

Abstract

The aim of this study was to introduce resting-state functional magnetic resonance imaging (rest-fMRI) capability for brain tumor surgical planning. rest-fMRI is an emerging functional neuroimaging technique potentially able to provide new insights into brain physiology and to provide useful information regarding brain tumors in preoperative and postoperative settings. rest-fMRI evaluates low-frequency fluctuations in the blood oxygen level–dependent signal while the subject is at rest during magnetic resonance imaging examination. Multiple resting-state networks have been identified, including the somatosensory, language, and visual networks, which are of primary importance for surgical planning. We discuss the feasibility of rest-fMRI examination before and after surgical resection of brain tumors in routine clinical practice and the usefulness of the information obtained for surgical planning in brain tumor resection. rest-fMRI is particularly useful for patients who are unable to cooperate with the task-based paradigm, such as children or patients who are sedated, paretic, or aphasic. Although standardization and validation of rest-fMRI are still ongoing, this technique is feasible and valuable and can be implemented for routine clinical surgical planning.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalWorld Neurosurgery
Volume131
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Blood oxygen level-dependent (BOLD) technique
  • Magnetic resonance imaging
  • Resting-state functional magnetic resonance imaging (rest-fMRI)

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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