Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

C. Babiloni; S. Lopez; C. Del Percio; G. Noce; M.T. Pascarelli; R. Lizio; S.J. Teipel; G. González-Escamilla; H. Bakardjian; N. George; E. Cavedo; S. Lista; P.A. Chiesa; A. Vergallo; P. Lemercier; G. Spinelli; M.J. Grothe; M.-C. Potier; F. Stocchi; R. Ferri; M.-O. Habert; F.J. Fraga; B. Dubois; H. Hampel

doi:10.1016/j.neurobiolaging.2020.01.012

Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

C. Babiloni, S. Lopez, C. Del Percio, G. Noce, M.T. Pascarelli, R. Lizio, S.J. Teipel, G. González-Escamilla, H. Bakardjian, N. George, E. Cavedo, S. Lista, P.A. Chiesa, A. Vergallo, P. Lemercier, G. Spinelli, M.J. Grothe, M.-C. Potier, F. Stocchi, R. FerriM.-O. Habert, F.J. Fraga, B. Dubois, H. Hampel

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.

Original language	English
Pages (from-to)	43-59
Number of pages	17
Journal	Neurobiology of Aging
Volume	90
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.01.012
Publication status	Published - 2020

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Babiloni, C., Lopez, S., Del Percio, C., Noce, G., Pascarelli, M. T., Lizio, R., Teipel, S. J., González-Escamilla, G., Bakardjian, H., George, N., Cavedo, E., Lista, S., Chiesa, P. A., Vergallo, A., Lemercier, P., Spinelli, G., Grothe, M. J., Potier, M-C., Stocchi, F., ... Hampel, H. (2020). Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study. Neurobiology of Aging, 90, 43-59. https://doi.org/10.1016/j.neurobiolaging.2020.01.012

Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study. / Babiloni, C.; Lopez, S.; Del Percio, C.; Noce, G.; Pascarelli, M.T.; Lizio, R.; Teipel, S.J.; González-Escamilla, G.; Bakardjian, H.; George, N.; Cavedo, E.; Lista, S.; Chiesa, P.A.; Vergallo, A.; Lemercier, P.; Spinelli, G.; Grothe, M.J.; Potier, M.-C.; Stocchi, F.; Ferri, R.; Habert, M.-O.; Fraga, F.J.; Dubois, B.; Hampel, H.

In: Neurobiology of Aging, Vol. 90, 2020, p. 43-59.

Research output: Contribution to journal › Article › peer-review

Babiloni, C, Lopez, S, Del Percio, C, Noce, G, Pascarelli, MT, Lizio, R, Teipel, SJ, González-Escamilla, G, Bakardjian, H, George, N, Cavedo, E, Lista, S, Chiesa, PA, Vergallo, A, Lemercier, P, Spinelli, G, Grothe, MJ, Potier, M-C, Stocchi, F, Ferri, R, Habert, M-O, Fraga, FJ, Dubois, B & Hampel, H 2020, 'Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study', Neurobiology of Aging, vol. 90, pp. 43-59. https://doi.org/10.1016/j.neurobiolaging.2020.01.012

Babiloni, C. ; Lopez, S. ; Del Percio, C. ; Noce, G. ; Pascarelli, M.T. ; Lizio, R. ; Teipel, S.J. ; González-Escamilla, G. ; Bakardjian, H. ; George, N. ; Cavedo, E. ; Lista, S. ; Chiesa, P.A. ; Vergallo, A. ; Lemercier, P. ; Spinelli, G. ; Grothe, M.J. ; Potier, M.-C. ; Stocchi, F. ; Ferri, R. ; Habert, M.-O. ; Fraga, F.J. ; Dubois, B. ; Hampel, H. / Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study. In: Neurobiology of Aging. 2020 ; Vol. 90. pp. 43-59.

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title = "Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study",

abstract = "Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.",

author = "C. Babiloni and S. Lopez and {Del Percio}, C. and G. Noce and M.T. Pascarelli and R. Lizio and S.J. Teipel and G. Gonz{\'a}lez-Escamilla and H. Bakardjian and N. George and E. Cavedo and S. Lista and P.A. Chiesa and A. Vergallo and P. Lemercier and G. Spinelli and M.J. Grothe and M.-C. Potier and F. Stocchi and R. Ferri and M.-O. Habert and F.J. Fraga and B. Dubois and H. Hampel",

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T1 - Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

AU - Babiloni, C.

AU - Lopez, S.

AU - Del Percio, C.

AU - Noce, G.

AU - Pascarelli, M.T.

AU - Lizio, R.

AU - Teipel, S.J.

AU - González-Escamilla, G.

AU - Bakardjian, H.

AU - George, N.

AU - Cavedo, E.

AU - Lista, S.

AU - Chiesa, P.A.

AU - Vergallo, A.

AU - Lemercier, P.

AU - Spinelli, G.

AU - Grothe, M.J.

AU - Potier, M.-C.

AU - Stocchi, F.

AU - Ferri, R.

AU - Habert, M.-O.

AU - Fraga, F.J.

AU - Dubois, B.

AU - Hampel, H.

N1 - Cited By :2 Export Date: 29 January 2021

PY - 2020

Y1 - 2020

N2 - Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.

AB - Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.

U2 - 10.1016/j.neurobiolaging.2020.01.012

DO - 10.1016/j.neurobiolaging.2020.01.012

M3 - Article

VL - 90

SP - 43

EP - 59

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -

Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

Abstract

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