TY - JOUR
T1 - Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study
AU - group, INSIGHT-preAD study
AU - Babiloni, Claudio
AU - Lopez, Susanna
AU - Del Percio, Claudio
AU - Noce, Giuseppe
AU - Pascarelli, Maria Teresa
AU - Lizio, Roberta
AU - Teipel, Stefan J.
AU - González-Escamilla, Gabriel
AU - Bakardjian, Hovagim
AU - George, Nathalie
AU - Cavedo, Enrica
AU - Lista, Simone
AU - Chiesa, Patrizia Andrea
AU - Vergallo, Andrea
AU - Lemercier, Pablo
AU - Spinelli, Giuseppe
AU - Grothe, Michel J.
AU - Potier, Marie Claude
AU - Stocchi, Fabrizio
AU - Ferri, Raffaele
AU - Habert, Marie Odile
AU - Fraga, Francisco J.
AU - Dubois, Bruno
AU - Hampel, Harald
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.
AB - Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.
KW - Alpha rhythms
KW - INSIGHT-preAD study
KW - Preclinical Alzheimer's disease (AD)
KW - Preclinical Alzheimer's neuropathology
KW - Resting state EEG rhythms
KW - Subjective memory complaint (SMC)
U2 - 10.1016/j.neurobiolaging.2020.01.012
DO - 10.1016/j.neurobiolaging.2020.01.012
M3 - Article
VL - 90
SP - 43
EP - 59
JO - Neurobiol. Aging
JF - Neurobiol. Aging
SN - 0197-4580
ER -