Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

INSIGHT-preAD study group, Claudio Babiloni, Susanna Lopez, Claudio Del Percio, Giuseppe Noce, Maria Teresa Pascarelli, Roberta Lizio, Stefan J. Teipel, Gabriel González-Escamilla, Hovagim Bakardjian, Nathalie George, Enrica Cavedo, Simone Lista, Patrizia Andrea Chiesa, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J. Grothe, Marie Claude Potier, Fabrizio StocchiRaffaele Ferri, Marie Odile Habert, Francisco J. Fraga, Bruno Dubois, Harald Hampel

Research output: Contribution to journalArticlepeer-review

Abstract

Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyes-closed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”). This effect may reflect cognitive reserve as no differences in brain gray-white matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.
Original languageEnglish
Pages (from-to)43-59
Number of pages17
JournalNeurobiol. Aging
Volume90
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • Alpha rhythms
  • INSIGHT-preAD study
  • Preclinical Alzheimer's disease (AD)
  • Preclinical Alzheimer's neuropathology
  • Resting state EEG rhythms
  • Subjective memory complaint (SMC)

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