Restless legs syndrome and pregnancy

Mauro Manconi, V. Govoni, A. De Vito, N. T. Economou, E. Cesnik, I. Casetta, G. Mollica, L. Ferini-Strambi, E. Granieri

Research output: Contribution to journalArticle


Objective: To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy and the puerperium. Methods: A structured clinical interview, assessing symptoms since the beginning of pregnancy, was performed to a population of 642 pregnant women at the time of delivery and at follow-up evaluation (1, 3, and 6 months after delivery). Main hematologic tests were also evaluated. A woman was considered affected if she met the International RLS Study Group criteria for RLS diagnosis. Results: Twenty-six percent of women were affected by RLS during their pregnancy. The disease was strongly related to the third trimester of pregnancy and tended to disappear reaching the time of delivery. Affected women presented lower values of hemoglobin and mean corpuscular volume compared with healthy subjects (both groups received the same supplemental iron and Mate therapy). Conclusions: Pregnancy is associated with transient restless legs syndrome.

Original languageEnglish
Pages (from-to)1065-1069
Number of pages5
Issue number6
Publication statusPublished - Sep 29 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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    Manconi, M., Govoni, V., De Vito, A., Economou, N. T., Cesnik, E., Casetta, I., Mollica, G., Ferini-Strambi, L., & Granieri, E. (2004). Restless legs syndrome and pregnancy. Neurology, 63(6), 1065-1069.