Restless legs syndrome in pregnancy and risk of gestational hypertension in a low risk population

Giovanna Esposito, Francesca Chiaffarino, Vanessa Odelli, Lucrezia Romiti, Mirella Di Martino, Fabio Parazzini

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It has been reported a relationship between Restless Legs Syndrome (RLS) and pregnancy-induced hypertension (PIH). In this brief paper we report the association between RLS and PHI observed in a study conducted in Italy. This is a cross sectional study. Eligible for the study were women aged >18 years who delivered in randomly selected days to the Department of Obstetrics of Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, the largest maternity hospital in Milan, Italy during 3 bimonthly periods in 2013-2015. The study protocol did not include any exclusion criteria. The researchers identified eligible women in the obstetric wards on randomly selected days within 3 days from delivery. Each woman who met the inclusion criteria agreed to be interviewed. A total of 648 women (median age 35, interquartile range 32-38) were identified. A questionnaire was administered during a face-to-face interview. This questionnaire included information about demographic characteristics and personal behavior. Diagnosis of RLS was established on the basis of the International Restless Legs Syndrome Study Group criteria. Out of the 648 interviewed women, 132 (20,4%, 95% CI: 17.3-23.5) met the criteria for diagnosis of RLS. Considering the 132 with and the 516 without RLS, 7(5,3%) and 29(5,6%) respectively had diagnosis of PHI (Odds Ratio adjusted for age: 0.89, 95% confidence interval 0.38-2.10). In conclusion despite the limitations our study suggests that the relationship between RLS syndrome and gestational hypertension should be more careful analyzed in different populations.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalItalian Journal of Gynaecology and Obstetrics
Issue number4
Publication statusPublished - Dec 1 2017

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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