Abstract
Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age- and sex-matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P <0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten-free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end-stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD.
| Original language | English |
|---|---|
| Pages (from-to) | 877-881 |
| Number of pages | 5 |
| Journal | Movement Disorders |
| Volume | 25 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - May 15 2010 |
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Keywords
- Celiac disease
- Restless legs syndrome
- Sleep disorders
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Restless legs syndrome is a common feature of adult celiac disease. / Moccia, Marcello; Pellecchia, Maria Teresa; Erro, Roberto; Zingone, Fabiana; Marelli, Sara; Barone, Damiano Giuseppe; Ciacci, Carolina; Strambi, Luigi Ferini; Barone, Paolo.
In: Movement Disorders, Vol. 25, No. 7, 15.05.2010, p. 877-881.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Restless legs syndrome is a common feature of adult celiac disease
AU - Moccia, Marcello
AU - Pellecchia, Maria Teresa
AU - Erro, Roberto
AU - Zingone, Fabiana
AU - Marelli, Sara
AU - Barone, Damiano Giuseppe
AU - Ciacci, Carolina
AU - Strambi, Luigi Ferini
AU - Barone, Paolo
PY - 2010/5/15
Y1 - 2010/5/15
N2 - Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age- and sex-matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P <0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten-free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end-stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD.
AB - Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age- and sex-matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P <0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten-free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end-stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD.
KW - Celiac disease
KW - Restless legs syndrome
KW - Sleep disorders
UR - http://www.scopus.com/inward/record.url?scp=77951968118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951968118&partnerID=8YFLogxK
U2 - 10.1002/mds.22903
DO - 10.1002/mds.22903
M3 - Article
C2 - 20461805
AN - SCOPUS:77951968118
VL - 25
SP - 877
EP - 881
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 7
ER -