Restless legs syndrome is a common feature of adult celiac disease

Marcello Moccia, Maria Teresa Pellecchia, Roberto Erro, Fabiana Zingone, Sara Marelli, Damiano Giuseppe Barone, Carolina Ciacci, Luigi Ferini Strambi, Paolo Barone

Research output: Contribution to journalArticle

Abstract

Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age- and sex-matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P <0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten-free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end-stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD.

Original languageEnglish
Pages (from-to)877-881
Number of pages5
JournalMovement Disorders
Volume25
Issue number7
DOIs
Publication statusPublished - May 15 2010

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Restless Legs Syndrome
Celiac Disease
Population
Iron
Peripheral Nervous System Diseases
Gluten-Free Diet
Iron-Deficiency Anemias
Neurologic Examination
Nervous System Diseases
Autoimmune Diseases

Keywords

  • Celiac disease
  • Restless legs syndrome
  • Sleep disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Moccia, M., Pellecchia, M. T., Erro, R., Zingone, F., Marelli, S., Barone, D. G., ... Barone, P. (2010). Restless legs syndrome is a common feature of adult celiac disease. Movement Disorders, 25(7), 877-881. https://doi.org/10.1002/mds.22903

Restless legs syndrome is a common feature of adult celiac disease. / Moccia, Marcello; Pellecchia, Maria Teresa; Erro, Roberto; Zingone, Fabiana; Marelli, Sara; Barone, Damiano Giuseppe; Ciacci, Carolina; Strambi, Luigi Ferini; Barone, Paolo.

In: Movement Disorders, Vol. 25, No. 7, 15.05.2010, p. 877-881.

Research output: Contribution to journalArticle

Moccia, M, Pellecchia, MT, Erro, R, Zingone, F, Marelli, S, Barone, DG, Ciacci, C, Strambi, LF & Barone, P 2010, 'Restless legs syndrome is a common feature of adult celiac disease', Movement Disorders, vol. 25, no. 7, pp. 877-881. https://doi.org/10.1002/mds.22903
Moccia M, Pellecchia MT, Erro R, Zingone F, Marelli S, Barone DG et al. Restless legs syndrome is a common feature of adult celiac disease. Movement Disorders. 2010 May 15;25(7):877-881. https://doi.org/10.1002/mds.22903
Moccia, Marcello ; Pellecchia, Maria Teresa ; Erro, Roberto ; Zingone, Fabiana ; Marelli, Sara ; Barone, Damiano Giuseppe ; Ciacci, Carolina ; Strambi, Luigi Ferini ; Barone, Paolo. / Restless legs syndrome is a common feature of adult celiac disease. In: Movement Disorders. 2010 ; Vol. 25, No. 7. pp. 877-881.
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