Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin

P. C. Braga, M. Dal Sasso, S. Maci, G. Piatti, R. Palmieri, L. Bruno, C. Albanese

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Senescence is a specific physiological evolution of human beings associated with a reduction in the functionality of several apparatus, including the immune system. Thymomodulin (TMD) contains thymus polypeptides (<10,000 D) and it has been used in a variety of disorders associated with defective immunological functions. The aim of this study was to investigate the effect on polymorphonuclear leukocyte (PMNs) phagocytosis and oxidative burst of a 6-week treatment with 160 mg/day TMD orally in elderly subjects (85.5 ± 9.7 years). Elderly subjects have impaired PMN phagocytosis and the following release of oxidant radicals. Treatment with TMD for 6-weeks had a restoring effect; phagocytosis and the phagocytic index were significantly improved, with increases of 132.6% and 112.5%. These findings indicate that TMD might be given to enhance the immunodefenses of immunocompromised elderly subjects. Luminol-dependent chemiluminescence was increased by 15.6%, which was not significant, indicating a different response between phagocytosis and release of oxidant radicals.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalJournal of Chemotherapy
Volume6
Issue number5
Publication statusPublished - 1994

Fingerprint

Phagocytosis
Neutrophils
Oxidants
Luminol
Respiratory Burst
Luminescence
Thymus Gland
Immune System
Peptides
thymomodulin
Therapeutics

Keywords

  • chemiluminescence
  • elderly subjects
  • improved phagocytosis
  • thymomodulin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Braga, P. C., Dal Sasso, M., Maci, S., Piatti, G., Palmieri, R., Bruno, L., & Albanese, C. (1994). Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. Journal of Chemotherapy, 6(5), 354-359.

Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. / Braga, P. C.; Dal Sasso, M.; Maci, S.; Piatti, G.; Palmieri, R.; Bruno, L.; Albanese, C.

In: Journal of Chemotherapy, Vol. 6, No. 5, 1994, p. 354-359.

Research output: Contribution to journalArticle

Braga, PC, Dal Sasso, M, Maci, S, Piatti, G, Palmieri, R, Bruno, L & Albanese, C 1994, 'Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin', Journal of Chemotherapy, vol. 6, no. 5, pp. 354-359.
Braga PC, Dal Sasso M, Maci S, Piatti G, Palmieri R, Bruno L et al. Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. Journal of Chemotherapy. 1994;6(5):354-359.
Braga, P. C. ; Dal Sasso, M. ; Maci, S. ; Piatti, G. ; Palmieri, R. ; Bruno, L. ; Albanese, C. / Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. In: Journal of Chemotherapy. 1994 ; Vol. 6, No. 5. pp. 354-359.
@article{f27e6de80f1c42458e7b4cf823acf8c2,
title = "Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin",
abstract = "Senescence is a specific physiological evolution of human beings associated with a reduction in the functionality of several apparatus, including the immune system. Thymomodulin (TMD) contains thymus polypeptides (<10,000 D) and it has been used in a variety of disorders associated with defective immunological functions. The aim of this study was to investigate the effect on polymorphonuclear leukocyte (PMNs) phagocytosis and oxidative burst of a 6-week treatment with 160 mg/day TMD orally in elderly subjects (85.5 ± 9.7 years). Elderly subjects have impaired PMN phagocytosis and the following release of oxidant radicals. Treatment with TMD for 6-weeks had a restoring effect; phagocytosis and the phagocytic index were significantly improved, with increases of 132.6{\%} and 112.5{\%}. These findings indicate that TMD might be given to enhance the immunodefenses of immunocompromised elderly subjects. Luminol-dependent chemiluminescence was increased by 15.6{\%}, which was not significant, indicating a different response between phagocytosis and release of oxidant radicals.",
keywords = "chemiluminescence, elderly subjects, improved phagocytosis, thymomodulin",
author = "Braga, {P. C.} and {Dal Sasso}, M. and S. Maci and G. Piatti and R. Palmieri and L. Bruno and C. Albanese",
year = "1994",
language = "English",
volume = "6",
pages = "354--359",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "5",

}

TY - JOUR

T1 - Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin

AU - Braga, P. C.

AU - Dal Sasso, M.

AU - Maci, S.

AU - Piatti, G.

AU - Palmieri, R.

AU - Bruno, L.

AU - Albanese, C.

PY - 1994

Y1 - 1994

N2 - Senescence is a specific physiological evolution of human beings associated with a reduction in the functionality of several apparatus, including the immune system. Thymomodulin (TMD) contains thymus polypeptides (<10,000 D) and it has been used in a variety of disorders associated with defective immunological functions. The aim of this study was to investigate the effect on polymorphonuclear leukocyte (PMNs) phagocytosis and oxidative burst of a 6-week treatment with 160 mg/day TMD orally in elderly subjects (85.5 ± 9.7 years). Elderly subjects have impaired PMN phagocytosis and the following release of oxidant radicals. Treatment with TMD for 6-weeks had a restoring effect; phagocytosis and the phagocytic index were significantly improved, with increases of 132.6% and 112.5%. These findings indicate that TMD might be given to enhance the immunodefenses of immunocompromised elderly subjects. Luminol-dependent chemiluminescence was increased by 15.6%, which was not significant, indicating a different response between phagocytosis and release of oxidant radicals.

AB - Senescence is a specific physiological evolution of human beings associated with a reduction in the functionality of several apparatus, including the immune system. Thymomodulin (TMD) contains thymus polypeptides (<10,000 D) and it has been used in a variety of disorders associated with defective immunological functions. The aim of this study was to investigate the effect on polymorphonuclear leukocyte (PMNs) phagocytosis and oxidative burst of a 6-week treatment with 160 mg/day TMD orally in elderly subjects (85.5 ± 9.7 years). Elderly subjects have impaired PMN phagocytosis and the following release of oxidant radicals. Treatment with TMD for 6-weeks had a restoring effect; phagocytosis and the phagocytic index were significantly improved, with increases of 132.6% and 112.5%. These findings indicate that TMD might be given to enhance the immunodefenses of immunocompromised elderly subjects. Luminol-dependent chemiluminescence was increased by 15.6%, which was not significant, indicating a different response between phagocytosis and release of oxidant radicals.

KW - chemiluminescence

KW - elderly subjects

KW - improved phagocytosis

KW - thymomodulin

UR - http://www.scopus.com/inward/record.url?scp=0028079738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028079738&partnerID=8YFLogxK

M3 - Article

C2 - 7861201

AN - SCOPUS:0028079738

VL - 6

SP - 354

EP - 359

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - 5

ER -