Restorative effect of total parenteral nutrition on natural killer cell activity in malnourished cancer patients

F. Bozzetti, L. Cozzaglio, M. L. Villa, E. Ferrario, D. Trabattoni

Research output: Contribution to journalArticlepeer-review

Abstract

Decreased natural killer cell activity (NKCA) is associated with malnutrition in both cancer and non-cancer patients. We have studied the effect of total parenteral nutrition (TPN) on NKCA in 9 malnourished cancer patients, candidates for surgery. TPN was administered for a median of 10 days (range 7-11), providing 1.5-fold the estimated resting energy expenditure, with 30% as fat. Calorie:nitrogen ratio was 150:1. Basal human recombinant interferon-α2a (rIFN-α2a) and human recombinant IL-2 (rIL-2) activated NKCA were measured, as were the main nutritional parameters, prior to and after TPN. NKCA increased in all patients and reached the normal range in 5, 3 and 4 subjects, respectively, for basal, rIFN-α2a and rIL-2 activated NKCA. As regards nutritional assessment, body weight and IgM levels significantly increased from 47.7 to 50.1 kg and from 174 to 237 mg/dl, respectively. This study demonstrates that a 10-day TPN course increases and sometimes restores normal NKCA. Such effect was constant and preceded nutritional changes.

Original languageEnglish
Pages (from-to)2023-2027
Number of pages5
JournalEuropean Journal of Cancer
Volume31
Issue number12
DOIs
Publication statusPublished - 1995

Keywords

  • cancer
  • malnutrition
  • natural killer cell
  • total parenteral nutrition

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology

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