Restoring TRAIL induced apoptosis using naturopat. Hercules joins hand with nature to triumph over lernaean hydra

Ammad Ahmad Farooqi, Cosmo Damiano Gadaleta, Girolamo Ranieri, Sundas Fayyaz, Ilaria Marech

Research output: Contribution to journalArticle

Abstract

Cancer is a multifaceted disease. Our deepened knowledge about genetic and biological mechanisms of cancer cells presents an opportunity to explore the inter-individual differences in the body’s ability to metabolize and respond to different nutrients. It is becoming progressively more understandable that the deregulation of several signaling pathways and the alterations in apoptotic response are some of the major determinants that underpin carcinogenesis. Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL)-mediated signaling has gained a remarkable appreciation because of its ability to selectively induce apoptosis in cancer cells leaving normal cells intact. However, technological advances have started to shed light on underlying mechanisms of resistance against TRAILinduced apoptosis in cancer cells. The impairment of TRAIL-mediated apoptosis includes various factors ranging from the loss or down regulation of TRAIL receptors or pro-apoptotic proteins to the up regulation of anti-apoptotic proteins. Intriguingly to mention that there is an ever-increasing number of natural herbal extracts (phytometabolites), which have been explored to date for their potential action in restoring apoptosis TRAIL-mediated in cancer cells. In this review, we will highlight the progress in understanding the mechanisms opted by phenolic compounds in overcoming TRAIL resistance.

Original languageEnglish
Pages (from-to)27-38
Number of pages12
JournalCurrent Genomics
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Apoptosis
  • Cancer
  • Caspases.
  • Herbal extracts
  • TRAIL

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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