Restraining effect of captopril on cardiovascular sympathetic efferent neural activity

Federico Lombardi, Tomaso Gnecchi-Ruscone, Nicola Montano, Maria L. Finocchiaro, Mauro Contini, Alberto Malliani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In 13 decerebrate cats we studied the effects of captopril (10mg/kg, intravenous bolus) on the background cardiac preganglionic sympathetic discharge and on its responsiveness to brief baroreceptor deactivations induced by premature ventricular contractions. Captopril caused a significant reduction of 57 ± 7% (from 2.4 ± 0.4 impulses/0.1 s) in sympathetic discharge, with a mean latency of 35 ± 3 min from the time of drug administration. In addition, the increase in cardiac sympathetic firing during premature ventricular contractions was markedly reduced, from 257 ± 30% to 70 ± 17%, before and after administration of captopril. These data indicate that captopril is not only likely to inhibit sympathetic discharge to the heart, but is also likely to restrain the excitatory sympathetic responses to baroreceptor deactivation.

Original languageEnglish
Pages (from-to)S55-S56
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Fingerprint

Captopril
Pressoreceptors
Ventricular Premature Complexes
Cats
Pharmaceutical Preparations

Keywords

  • Baroreflex deactivation
  • Captopril
  • Premature ventricular contraction
  • Sympathetic discharge

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Restraining effect of captopril on cardiovascular sympathetic efferent neural activity. / Lombardi, Federico; Gnecchi-Ruscone, Tomaso; Montano, Nicola; Finocchiaro, Maria L.; Contini, Mauro; Malliani, Alberto.

In: Journal of Hypertension, Supplement, Vol. 7, 1989, p. S55-S56.

Research output: Contribution to journalArticle

@article{eae88f5c89ef42b4892c2421fc1eee2e,
title = "Restraining effect of captopril on cardiovascular sympathetic efferent neural activity",
abstract = "In 13 decerebrate cats we studied the effects of captopril (10mg/kg, intravenous bolus) on the background cardiac preganglionic sympathetic discharge and on its responsiveness to brief baroreceptor deactivations induced by premature ventricular contractions. Captopril caused a significant reduction of 57 ± 7{\%} (from 2.4 ± 0.4 impulses/0.1 s) in sympathetic discharge, with a mean latency of 35 ± 3 min from the time of drug administration. In addition, the increase in cardiac sympathetic firing during premature ventricular contractions was markedly reduced, from 257 ± 30{\%} to 70 ± 17{\%}, before and after administration of captopril. These data indicate that captopril is not only likely to inhibit sympathetic discharge to the heart, but is also likely to restrain the excitatory sympathetic responses to baroreceptor deactivation.",
keywords = "Baroreflex deactivation, Captopril, Premature ventricular contraction, Sympathetic discharge",
author = "Federico Lombardi and Tomaso Gnecchi-Ruscone and Nicola Montano and Finocchiaro, {Maria L.} and Mauro Contini and Alberto Malliani",
year = "1989",
language = "English",
volume = "7",
pages = "S55--S56",
journal = "Journal of Hypertension, Supplement",
issn = "0952-1178",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Restraining effect of captopril on cardiovascular sympathetic efferent neural activity

AU - Lombardi, Federico

AU - Gnecchi-Ruscone, Tomaso

AU - Montano, Nicola

AU - Finocchiaro, Maria L.

AU - Contini, Mauro

AU - Malliani, Alberto

PY - 1989

Y1 - 1989

N2 - In 13 decerebrate cats we studied the effects of captopril (10mg/kg, intravenous bolus) on the background cardiac preganglionic sympathetic discharge and on its responsiveness to brief baroreceptor deactivations induced by premature ventricular contractions. Captopril caused a significant reduction of 57 ± 7% (from 2.4 ± 0.4 impulses/0.1 s) in sympathetic discharge, with a mean latency of 35 ± 3 min from the time of drug administration. In addition, the increase in cardiac sympathetic firing during premature ventricular contractions was markedly reduced, from 257 ± 30% to 70 ± 17%, before and after administration of captopril. These data indicate that captopril is not only likely to inhibit sympathetic discharge to the heart, but is also likely to restrain the excitatory sympathetic responses to baroreceptor deactivation.

AB - In 13 decerebrate cats we studied the effects of captopril (10mg/kg, intravenous bolus) on the background cardiac preganglionic sympathetic discharge and on its responsiveness to brief baroreceptor deactivations induced by premature ventricular contractions. Captopril caused a significant reduction of 57 ± 7% (from 2.4 ± 0.4 impulses/0.1 s) in sympathetic discharge, with a mean latency of 35 ± 3 min from the time of drug administration. In addition, the increase in cardiac sympathetic firing during premature ventricular contractions was markedly reduced, from 257 ± 30% to 70 ± 17%, before and after administration of captopril. These data indicate that captopril is not only likely to inhibit sympathetic discharge to the heart, but is also likely to restrain the excitatory sympathetic responses to baroreceptor deactivation.

KW - Baroreflex deactivation

KW - Captopril

KW - Premature ventricular contraction

KW - Sympathetic discharge

UR - http://www.scopus.com/inward/record.url?scp=0024947016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024947016&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - S55-S56

JO - Journal of Hypertension, Supplement

JF - Journal of Hypertension, Supplement

SN - 0952-1178

ER -