Restricted heterogeneity of antibody to gp120 and p24 in AIDS

L. M E Grimaldi; R. P. Roos; S. G. Devare; W. G. Robey; J. M. Casey; M. E. Gurney; B. R. Apatoff; A. Lazzarin

Restricted heterogeneity of antibody to gp120 and p24 in AIDS

L. M E Grimaldi, R. P. Roos, S. G. Devare, W. G. Robey, J. M. Casey, M. E. Gurney, B. R. Apatoff, A. Lazzarin

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern, this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation

Original language	English
Pages (from-to)	114-117
Number of pages	4
Journal	Journal of Immunology
Volume	141
Issue number	1
Publication status	Published - 1988

ASJC Scopus subject areas

Immunology

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title = "Restricted heterogeneity of antibody to gp120 and p24 in AIDS",

abstract = "Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern, this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation",

author = "Grimaldi, {L. M E} and Roos, {R. P.} and Devare, {S. G.} and Robey, {W. G.} and Casey, {J. M.} and Gurney, {M. E.} and Apatoff, {B. R.} and A. Lazzarin",

year = "1988",

language = "English",

volume = "141",

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T1 - Restricted heterogeneity of antibody to gp120 and p24 in AIDS

AU - Grimaldi, L. M E

AU - Roos, R. P.

AU - Devare, S. G.

AU - Robey, W. G.

AU - Casey, J. M.

AU - Gurney, M. E.

AU - Apatoff, B. R.

AU - Lazzarin, A.

PY - 1988

Y1 - 1988

N2 - Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern, this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation

AB - Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern, this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation

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