Restriction enzyme analysis of human leukemic mitochondrial DNA

Alessandro M. Gianni, Riccardo Dalla Favera, Elio Polli

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondrial DNA from both normal human tissue and leukemic human leukocytes (AML and CML) were analyzed by restriction-enzyme digestion, polyacrylamide gradient gel electrophoresis and ethidium bromide staining. Both normal and leukemic human mitochondrial DNA show molecular heterogeneity from individual to individual. This intraspecies variability is significantly higher in leukemias, where most of the cases show unique patterns. We suggest that this variability might be a molecular symptom of mutagenesis.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalLeukemia Research
Volume4
Issue number1
DOIs
Publication statusPublished - 1980

Keywords

  • Mitochondrial DNA
  • mutagenesis
  • myelogenous leukemia
  • restriction enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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