TY - JOUR
T1 - Result of liver resection as treatment for metastases from noncolorectal cancer
AU - Benevento, Angelo
AU - Boni, Luigi
AU - Frediani, Lorenzo
AU - Ferrari, Alberta
AU - Dionigi, Renzo
PY - 2000
Y1 - 2000
N2 - Background and Objectives: While liver resection for metastatic disease from colorectal cancer extends survival in selected patients, the efficacy of hepatectomy for metastases from other malignancies has not been defined. Methods: Between 1988 and 1998, 20 hepatic resections were performed in 18 patients (2 underwent a double resection due to recurrence) as treatment of noncolorectal metastases. One-, 2-, and 5-year overall and disease-related actuarial survival rates were calculated. Results: No intraoperative or early postoperative deaths were reported. Seven minor (30%) and 1 major (5%) postoperative complications occurred; mean blood loss was 401 ± 324 ml. In 25% of patients, intra- or postoperative blood transfusion was needed. The mean postoperative hospital stay was 13.2 days (range 9-23). The overall actuarial survival rate was 54% at 1 year, 42% at 2 years, and 21% at 5 years (mean 38 ± 11 months). Survival is related to the primary tumor nature. Conclusions: Hepatic resection for metastases from noncolorectal carcinoma is safe and feasible, with a relatively low incidence of intra- or postoperative complications and a short hospital stay. Although it achieves good results in terms of survival in patients suffering from neuroendocrine metastases, it could also have a cytoreductive effect for other tumors. (C) 2000 Wiley-Liss, Inc.
AB - Background and Objectives: While liver resection for metastatic disease from colorectal cancer extends survival in selected patients, the efficacy of hepatectomy for metastases from other malignancies has not been defined. Methods: Between 1988 and 1998, 20 hepatic resections were performed in 18 patients (2 underwent a double resection due to recurrence) as treatment of noncolorectal metastases. One-, 2-, and 5-year overall and disease-related actuarial survival rates were calculated. Results: No intraoperative or early postoperative deaths were reported. Seven minor (30%) and 1 major (5%) postoperative complications occurred; mean blood loss was 401 ± 324 ml. In 25% of patients, intra- or postoperative blood transfusion was needed. The mean postoperative hospital stay was 13.2 days (range 9-23). The overall actuarial survival rate was 54% at 1 year, 42% at 2 years, and 21% at 5 years (mean 38 ± 11 months). Survival is related to the primary tumor nature. Conclusions: Hepatic resection for metastases from noncolorectal carcinoma is safe and feasible, with a relatively low incidence of intra- or postoperative complications and a short hospital stay. Although it achieves good results in terms of survival in patients suffering from neuroendocrine metastases, it could also have a cytoreductive effect for other tumors. (C) 2000 Wiley-Liss, Inc.
KW - Liver resection
KW - Noncolorectal metastases
KW - Survival
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U2 - 10.1002/1096-9098(200005)74:1<24::AID-JSO6>3.0.CO;2-V
DO - 10.1002/1096-9098(200005)74:1<24::AID-JSO6>3.0.CO;2-V
M3 - Article
C2 - 10861604
AN - SCOPUS:0034043894
VL - 74
SP - 24
EP - 29
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -