Abstract
Background. Somatostatin receptor imaging with 111In-pentetreotide is widely accepted as an essential step in the management of patients affected by neuroendocrine tumours of the gastro-entero-pancreatic tract. Many data are already available on the high sensitivity of this technique. Methods. We present a review of the published data together with the results of a study involving 253 patients submitted to somatostatin receptor imaging in three Italian hospitals. The patients were divided into two groups treated with different acquisition and processing protocols. Results. The overall sensitivity was as high as (169/176) 96% in both groups, while the specificity was higher in the group in which semi-quantitative evaluation of somatostatin receptor density was performed: (23/26) 88% vs (39/51) 76%. The use of this method is recommended to increase the specificity of 111In-pentetreotide imaging. Conclusions. Our results with somatostatin receptor imaging in neuroendocrine tumours of the gastro-entero-pancreatic tract demonstrate that all figures of merit are excellent when imaging is accurately performed and analysed by experienced operators.
| Original language | English |
|---|---|
| Pages (from-to) | 42-49 |
| Number of pages | 8 |
| Journal | Quarterly Journal of Nuclear Medicine |
| Volume | 44 |
| Issue number | 1 |
| Publication status | Published - 2000 |
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Keywords
- Indium radioisotopes
- Gastrointestinal neoplasms
- Neuroendocrine tumours
- Receptors somatostatin analysis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Results and potential of somatostatin receptor imaging in gastroenteropancreatic tract tumours. / Chiti, A.; Briganti, V.; Fanti, S.; Monetti, N.; Masi, R.; Bombardieri, E.
In: Quarterly Journal of Nuclear Medicine, Vol. 44, No. 1, 2000, p. 42-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Results and potential of somatostatin receptor imaging in gastroenteropancreatic tract tumours
AU - Chiti, A.
AU - Briganti, V.
AU - Fanti, S.
AU - Monetti, N.
AU - Masi, R.
AU - Bombardieri, E.
PY - 2000
Y1 - 2000
N2 - Background. Somatostatin receptor imaging with 111In-pentetreotide is widely accepted as an essential step in the management of patients affected by neuroendocrine tumours of the gastro-entero-pancreatic tract. Many data are already available on the high sensitivity of this technique. Methods. We present a review of the published data together with the results of a study involving 253 patients submitted to somatostatin receptor imaging in three Italian hospitals. The patients were divided into two groups treated with different acquisition and processing protocols. Results. The overall sensitivity was as high as (169/176) 96% in both groups, while the specificity was higher in the group in which semi-quantitative evaluation of somatostatin receptor density was performed: (23/26) 88% vs (39/51) 76%. The use of this method is recommended to increase the specificity of 111In-pentetreotide imaging. Conclusions. Our results with somatostatin receptor imaging in neuroendocrine tumours of the gastro-entero-pancreatic tract demonstrate that all figures of merit are excellent when imaging is accurately performed and analysed by experienced operators.
AB - Background. Somatostatin receptor imaging with 111In-pentetreotide is widely accepted as an essential step in the management of patients affected by neuroendocrine tumours of the gastro-entero-pancreatic tract. Many data are already available on the high sensitivity of this technique. Methods. We present a review of the published data together with the results of a study involving 253 patients submitted to somatostatin receptor imaging in three Italian hospitals. The patients were divided into two groups treated with different acquisition and processing protocols. Results. The overall sensitivity was as high as (169/176) 96% in both groups, while the specificity was higher in the group in which semi-quantitative evaluation of somatostatin receptor density was performed: (23/26) 88% vs (39/51) 76%. The use of this method is recommended to increase the specificity of 111In-pentetreotide imaging. Conclusions. Our results with somatostatin receptor imaging in neuroendocrine tumours of the gastro-entero-pancreatic tract demonstrate that all figures of merit are excellent when imaging is accurately performed and analysed by experienced operators.
KW - Indium radioisotopes
KW - Gastrointestinal neoplasms
KW - Neuroendocrine tumours
KW - Receptors somatostatin analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=0034115734&partnerID=8YFLogxK
M3 - Article
VL - 44
SP - 42
EP - 49
JO - Journal of Nuclear Medicine and Allied Sciences
JF - Journal of Nuclear Medicine and Allied Sciences
SN - 1124-3937
IS - 1
ER -