TY - JOUR
T1 - Results from a single-blind, randomized study comparing the impact of different ablation approaches on long-term procedure outcome in coexistent atrial fibrillation and flutter (approval)
AU - Mohanty, Sanghamitra
AU - Mohanty, Prasant
AU - Di Biase, Luigi
AU - Bai, Rong
AU - Santangeli, Pasquale
AU - Casella, Michela
AU - Russo, Antonio Dello
AU - Tondo, Claudio
AU - Themistoclakis, Sakis
AU - Raviele, Antonio
AU - Rossillo, Antonio
AU - Corrado, Andrea
AU - Pelargonio, Gemma
AU - Forleo, Giovanni
AU - Natale, Andrea
PY - 2013/5/7
Y1 - 2013/5/7
N2 - BACKGROUND-: This study examined the impact of different ablation strategies on atrial fibrillation (AF) recurrence and quality of life in coexistent AF and atrial flutter (AFL). METHODS AND RESULTS-: Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1, AF±AFL ablation (n=182), or group 2, AFL ablation only (n=178). AF recurrence was evaluated with event recording and 7-day Holter at 3, 6, 9, and 12-month follow-ups. Quality of life was assessed at baseline and at the 12-month follow-up with 4 questionnaires: the Medical Outcome Study Short Form, the Hospital Anxiety and Depression Score, the Beck Depression Inventory, and the State-Trait Anxiety Inventory. Of the 182 patients in group 1, 58 (age, 63±8 years; 78% male; left ventricular ejection fraction, 59±8%) had AF+AFL ablation and 124 (age, 61±11 years; 72% male; left ventricular ejection fraction, 59±7%) had AF ablation only. In group 2 (age, 62±9 years; 76% male; left ventricular ejection fraction, 58±10%), only AFL was ablated by achieving bidirectional isthmus conduction block. Baseline characteristics were not different across groups. At 21±9 months of follow-up, 117 in group 1 (64%) and 34 in group 2 (19%) were arrhythmia free (P
AB - BACKGROUND-: This study examined the impact of different ablation strategies on atrial fibrillation (AF) recurrence and quality of life in coexistent AF and atrial flutter (AFL). METHODS AND RESULTS-: Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1, AF±AFL ablation (n=182), or group 2, AFL ablation only (n=178). AF recurrence was evaluated with event recording and 7-day Holter at 3, 6, 9, and 12-month follow-ups. Quality of life was assessed at baseline and at the 12-month follow-up with 4 questionnaires: the Medical Outcome Study Short Form, the Hospital Anxiety and Depression Score, the Beck Depression Inventory, and the State-Trait Anxiety Inventory. Of the 182 patients in group 1, 58 (age, 63±8 years; 78% male; left ventricular ejection fraction, 59±8%) had AF+AFL ablation and 124 (age, 61±11 years; 72% male; left ventricular ejection fraction, 59±7%) had AF ablation only. In group 2 (age, 62±9 years; 76% male; left ventricular ejection fraction, 58±10%), only AFL was ablated by achieving bidirectional isthmus conduction block. Baseline characteristics were not different across groups. At 21±9 months of follow-up, 117 in group 1 (64%) and 34 in group 2 (19%) were arrhythmia free (P
KW - ablation techniques
KW - atrial fibrillation
KW - atrial flutter
KW - pulmonary veins
KW - quality of life
KW - Recurrence
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U2 - 10.1161/CIRCULATIONAHA.113.001855
DO - 10.1161/CIRCULATIONAHA.113.001855
M3 - Article
C2 - 23572499
AN - SCOPUS:84877303385
VL - 127
SP - 1853
EP - 1860
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 18
ER -