Results from a single-blind, randomized study comparing the impact of different ablation approaches on long-term procedure outcome in coexistent atrial fibrillation and flutter (approval)

Sanghamitra Mohanty, Prasant Mohanty, Luigi Di Biase, Rong Bai, Pasquale Santangeli, Michela Casella, Antonio Dello Russo, Claudio Tondo, Sakis Themistoclakis, Antonio Raviele, Antonio Rossillo, Andrea Corrado, Gemma Pelargonio, Giovanni Forleo, Andrea Natale

Research output: Contribution to journalArticle

Abstract

BACKGROUND-: This study examined the impact of different ablation strategies on atrial fibrillation (AF) recurrence and quality of life in coexistent AF and atrial flutter (AFL). METHODS AND RESULTS-: Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1, AF±AFL ablation (n=182), or group 2, AFL ablation only (n=178). AF recurrence was evaluated with event recording and 7-day Holter at 3, 6, 9, and 12-month follow-ups. Quality of life was assessed at baseline and at the 12-month follow-up with 4 questionnaires: the Medical Outcome Study Short Form, the Hospital Anxiety and Depression Score, the Beck Depression Inventory, and the State-Trait Anxiety Inventory. Of the 182 patients in group 1, 58 (age, 63±8 years; 78% male; left ventricular ejection fraction, 59±8%) had AF+AFL ablation and 124 (age, 61±11 years; 72% male; left ventricular ejection fraction, 59±7%) had AF ablation only. In group 2 (age, 62±9 years; 76% male; left ventricular ejection fraction, 58±10%), only AFL was ablated by achieving bidirectional isthmus conduction block. Baseline characteristics were not different across groups. At 21±9 months of follow-up, 117 in group 1 (64%) and 34 in group 2 (19%) were arrhythmia free (P

Original languageEnglish
Pages (from-to)1853-1860
Number of pages8
JournalCirculation
Volume127
Issue number18
DOIs
Publication statusPublished - May 7 2013

    Fingerprint

Keywords

  • ablation techniques
  • atrial fibrillation
  • atrial flutter
  • pulmonary veins
  • quality of life
  • Recurrence

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Mohanty, S., Mohanty, P., Di Biase, L., Bai, R., Santangeli, P., Casella, M., Russo, A. D., Tondo, C., Themistoclakis, S., Raviele, A., Rossillo, A., Corrado, A., Pelargonio, G., Forleo, G., & Natale, A. (2013). Results from a single-blind, randomized study comparing the impact of different ablation approaches on long-term procedure outcome in coexistent atrial fibrillation and flutter (approval). Circulation, 127(18), 1853-1860. https://doi.org/10.1161/CIRCULATIONAHA.113.001855