Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease

Laurent Peyrin-Biroulet, Marc Ferrante, Fernando Magro, Simon Campbell, Denis Franchimont, Herma Fidder, Hans Strid, Sandro Ardizzone, Gigi Veereman-Wauters, Jean Baptiste Chevaux, Mathieu Allez, Silvio Danese, Andreas Sturm

Research output: Contribution to journalArticle

Abstract

Over the past years, mucosal healing has emerged as a major therapeutic goal in clinical trials in inflammatory bowel diseases. Accumulating evidence indicates that mucosal healing may change the natural course of the disease by decreasing the need for surgery and reducing hospitalization rates in both ulcerative colitis and Crohn's disease. Mucosal healing may also prevent the development of long-term disease complications, such as bowel damage in Crohn's disease and colorectal cancer in ulcerative colitis. Histologic healing may be the ultimate therapeutic goal in ulcerative colitis, whereas its impact on the course of Crohn's disease is unknown. Complete mucosal healing may be required before considering drug withdrawal. Targeting early Crohn's disease is more effective than approaches aimed at healing mucosa in longstanding disease. Several questions remain to be answered: should mucosal healing be systematically used in clinical practice? Should we optimize therapies to achieve mucosal healing? What is the degree of intestinal healing that is required to change the disease course? Large prospective studies addressing these issues are needed.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalJournal of Crohn's & colitis
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Crohn's disease;
  • Inflammatory Bowel Disease;
  • Mucosal healing
  • Ulcerative colitis;

ASJC Scopus subject areas

  • Gastroenterology

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    Peyrin-Biroulet, L., Ferrante, M., Magro, F., Campbell, S., Franchimont, D., Fidder, H., Strid, H., Ardizzone, S., Veereman-Wauters, G., Chevaux, J. B., Allez, M., Danese, S., & Sturm, A. (2011). Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease. Journal of Crohn's & colitis, 5(5), 477-483. https://doi.org/10.1016/j.crohns.2011.06.009