Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne

Stefano Veraldi, Giuseppe Micali, Enzo Berardesca, Federica Dall'Oglio, Jo Linda Sinagra, Elena Guanziroli

Research output: Contribution to journalArticle

Abstract

Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mild-to-moderate acne. Methods: In this eight-week multicenter study, patients were randomized to either a hydrogen peroxide-based or a benzoyl peroxide-based regimen.The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit. Results: Both treatment regimens were associated with improvement of GAGS score at Week 8 compared to baseline (p<0.0001). GAGS score did not differ significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly effective and cosmetically acceptable. Conclusion: A novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide-based regimen in the treatment of mild-to-moderate acne.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalJournal of Clinical and Aesthetic Dermatology
Volume9
Issue number10
Publication statusPublished - Oct 2016

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Benzoyl Peroxide
Acne Vulgaris
Hydrogen Peroxide
Randomized Controlled Trials
Cosmetics
Research Personnel
Patient Satisfaction
Multicenter Studies
Therapeutics
Outcome Assessment (Health Care)
Safety

Keywords

  • Journal Article

Cite this

Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne. / Veraldi, Stefano; Micali, Giuseppe; Berardesca, Enzo; Dall'Oglio, Federica; Sinagra, Jo Linda; Guanziroli, Elena.

In: Journal of Clinical and Aesthetic Dermatology, Vol. 9, No. 10, 10.2016, p. 50-54.

Research output: Contribution to journalArticle

Veraldi, Stefano ; Micali, Giuseppe ; Berardesca, Enzo ; Dall'Oglio, Federica ; Sinagra, Jo Linda ; Guanziroli, Elena. / Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide-based Kit versus a Benzoyl Peroxide-based Kit in Mild-to-moderate Acne. In: Journal of Clinical and Aesthetic Dermatology. 2016 ; Vol. 9, No. 10. pp. 50-54.
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