Results of a Phase II Study of Short-Course Accelerated Radiation Therapy (SHARON) for Multiple Brain Metastases

Luciana Caravatta, Francesco Deodato, Marica Ferro, Gabriella Macchia, Mariangela Massaccesi, Savino Cilla, Rosa Tambaro, Samantha Mignogna, Gilbert D A Padula, Michela Musacchio, Mariano Flocco, Giampaolo Cantore, Andrea Scapati, Solomon Bogale, Mario Balducci, Vincenzo Valentini, Numa Cellini, Alessio G. Morganti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess the effectiveness of a SHort-course Accelerated RadiatiON therapy (SHARON) in the treatment of patients with multiple brain metastases. Materials and Methods: A phase II clinical trial was designed. Eligibility criteria included patients with at least 3 brain metastases or metastatic disease in >3 organ systems, and Eastern Cooperative Oncology Group performance status of ≤3. Fifty patients were treated with whole brain radiotherapy at 18 Gy (4.5 Gy per fraction) in 2 days with a twice daily fractionation. The primary endpoint was the assessment of efficacy in terms of overall survival. Results: Characteristics of the 50 enrolled patients were: male/female: 24/26; median age: 65 years (range, 45 to 80 y). Eastern Cooperative Oncology Group performance status was

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume38
Issue number4
DOIs
Publication statusPublished - Aug 6 2015

Keywords

  • brain metastases
  • palliative care
  • quality of life
  • radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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