Results of a Phase II Study of Short-Course Accelerated Radiation Therapy (SHARON) for Multiple Brain Metastases

Luciana Caravatta, Francesco Deodato, Marica Ferro, Gabriella Macchia, Mariangela Massaccesi, Savino Cilla, Rosa Tambaro, Samantha Mignogna, Gilbert D A Padula, Michela Musacchio, Mariano Flocco, Giampaolo Cantore, Andrea Scapati, Solomon Bogale, Mario Balducci, Vincenzo Valentini, Numa Cellini, Alessio G. Morganti

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the effectiveness of a SHort-course Accelerated RadiatiON therapy (SHARON) in the treatment of patients with multiple brain metastases. Materials and Methods: A phase II clinical trial was designed. Eligibility criteria included patients with at least 3 brain metastases or metastatic disease in >3 organ systems, and Eastern Cooperative Oncology Group performance status of ≤3. Fifty patients were treated with whole brain radiotherapy at 18 Gy (4.5 Gy per fraction) in 2 days with a twice daily fractionation. The primary endpoint was the assessment of efficacy in terms of overall survival. Results: Characteristics of the 50 enrolled patients were: male/female: 24/26; median age: 65 years (range, 45 to 80 y). Eastern Cooperative Oncology Group performance status was

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume38
Issue number4
DOIs
Publication statusPublished - Aug 6 2015

Keywords

  • brain metastases
  • palliative care
  • quality of life
  • radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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  • Cite this

    Caravatta, L., Deodato, F., Ferro, M., Macchia, G., Massaccesi, M., Cilla, S., Tambaro, R., Mignogna, S., Padula, G. D. A., Musacchio, M., Flocco, M., Cantore, G., Scapati, A., Bogale, S., Balducci, M., Valentini, V., Cellini, N., & Morganti, A. G. (2015). Results of a Phase II Study of Short-Course Accelerated Radiation Therapy (SHARON) for Multiple Brain Metastases. American Journal of Clinical Oncology: Cancer Clinical Trials, 38(4), 395-400. https://doi.org/10.1097/COC.0b013e3182a0e826