Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy

Laura Colombo, Gianluigi Corti, Filippo Magri, Alessandro Marocchi, Paolo Brambilla, Carla Crespi, Luigi Manieri, Sergio Ghezzi, Daniela Giannone, Luca Merlino, Paolo Mocarelli

Research output: Contribution to journalArticle

Abstract

Study objective - Screening recommendations for colorectal cancer include sigmoidoscopy in asymptomatic, average risk persons aged 50 and over and colonoscopy every three to five years in high risk groups. Little is known about the eligible population's compliance with endoscopic screening. This is the first Italian report of an endoscopic screening programme for colorectal cancer patients) relatives. Design - In 1986, a pilot project for colorectal cancer screening by endoscopy in high risk subjects was started in the Desio (Milan, Italy) public health service region. The results obtained after seven years are described. Setting - The names of 536 inhabitants with colorectal cancer diagnosed between January 1975 and December 1984 and their relatives' addresses were obtained from the Regione Lombardia Health System records and from the municipal registry offices respectively. Participants - From October 1986 to October 1993, 778 first degree relatives aged 20-75 were offered colonoscopy. Main results - After seven years, 233 (29.9%) had undergone endoscopic examination, mostly up to the splenic flexure. Being > 60 in age at the start of the programme negatively affected participation (p <0.05). Two cancers were detected and adenomatous polyps were found in another 24 of those screened (frequencies: 0.9% and 10.3% respectively). Male gender (p <0.05), increasing age in males (p <0.01), and two or more affected relatives in females (p <0.01) positively affected the frequency of polyps detection. Conclusion - These results suggest that about 30% of the eligible population would comply at least with sigmoidoscopic screening. The collaboration of family doctors and more widespread public information about the ability to cure colorectal cancer are necessary for better compliance.

Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalJournal of Epidemiology and Community Health
Volume51
Issue number4
Publication statusPublished - 1997

Fingerprint

Italy
Colorectal Neoplasms
Colonoscopy
Adenomatous Polyps
Sigmoidoscopy
Transverse Colon
Aptitude
United States Public Health Service
Polyps
Early Detection of Cancer
Population
Endoscopy
Compliance
Names
Registries
Health
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Colombo, L., Corti, G., Magri, F., Marocchi, A., Brambilla, P., Crespi, C., ... Mocarelli, P. (1997). Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy. Journal of Epidemiology and Community Health, 51(4), 453-458.

Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy. / Colombo, Laura; Corti, Gianluigi; Magri, Filippo; Marocchi, Alessandro; Brambilla, Paolo; Crespi, Carla; Manieri, Luigi; Ghezzi, Sergio; Giannone, Daniela; Merlino, Luca; Mocarelli, Paolo.

In: Journal of Epidemiology and Community Health, Vol. 51, No. 4, 1997, p. 453-458.

Research output: Contribution to journalArticle

Colombo, L, Corti, G, Magri, F, Marocchi, A, Brambilla, P, Crespi, C, Manieri, L, Ghezzi, S, Giannone, D, Merlino, L & Mocarelli, P 1997, 'Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy', Journal of Epidemiology and Community Health, vol. 51, no. 4, pp. 453-458.
Colombo, Laura ; Corti, Gianluigi ; Magri, Filippo ; Marocchi, Alessandro ; Brambilla, Paolo ; Crespi, Carla ; Manieri, Luigi ; Ghezzi, Sergio ; Giannone, Daniela ; Merlino, Luca ; Mocarelli, Paolo. / Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy. In: Journal of Epidemiology and Community Health. 1997 ; Vol. 51, No. 4. pp. 453-458.
@article{1923a4c3e1724d349b515db97b159953,
title = "Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy",
abstract = "Study objective - Screening recommendations for colorectal cancer include sigmoidoscopy in asymptomatic, average risk persons aged 50 and over and colonoscopy every three to five years in high risk groups. Little is known about the eligible population's compliance with endoscopic screening. This is the first Italian report of an endoscopic screening programme for colorectal cancer patients) relatives. Design - In 1986, a pilot project for colorectal cancer screening by endoscopy in high risk subjects was started in the Desio (Milan, Italy) public health service region. The results obtained after seven years are described. Setting - The names of 536 inhabitants with colorectal cancer diagnosed between January 1975 and December 1984 and their relatives' addresses were obtained from the Regione Lombardia Health System records and from the municipal registry offices respectively. Participants - From October 1986 to October 1993, 778 first degree relatives aged 20-75 were offered colonoscopy. Main results - After seven years, 233 (29.9{\%}) had undergone endoscopic examination, mostly up to the splenic flexure. Being > 60 in age at the start of the programme negatively affected participation (p <0.05). Two cancers were detected and adenomatous polyps were found in another 24 of those screened (frequencies: 0.9{\%} and 10.3{\%} respectively). Male gender (p <0.05), increasing age in males (p <0.01), and two or more affected relatives in females (p <0.01) positively affected the frequency of polyps detection. Conclusion - These results suggest that about 30{\%} of the eligible population would comply at least with sigmoidoscopic screening. The collaboration of family doctors and more widespread public information about the ability to cure colorectal cancer are necessary for better compliance.",
author = "Laura Colombo and Gianluigi Corti and Filippo Magri and Alessandro Marocchi and Paolo Brambilla and Carla Crespi and Luigi Manieri and Sergio Ghezzi and Daniela Giannone and Luca Merlino and Paolo Mocarelli",
year = "1997",
language = "English",
volume = "51",
pages = "453--458",
journal = "Journal of Epidemiology and Community Health",
issn = "0143-005X",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy

AU - Colombo, Laura

AU - Corti, Gianluigi

AU - Magri, Filippo

AU - Marocchi, Alessandro

AU - Brambilla, Paolo

AU - Crespi, Carla

AU - Manieri, Luigi

AU - Ghezzi, Sergio

AU - Giannone, Daniela

AU - Merlino, Luca

AU - Mocarelli, Paolo

PY - 1997

Y1 - 1997

N2 - Study objective - Screening recommendations for colorectal cancer include sigmoidoscopy in asymptomatic, average risk persons aged 50 and over and colonoscopy every three to five years in high risk groups. Little is known about the eligible population's compliance with endoscopic screening. This is the first Italian report of an endoscopic screening programme for colorectal cancer patients) relatives. Design - In 1986, a pilot project for colorectal cancer screening by endoscopy in high risk subjects was started in the Desio (Milan, Italy) public health service region. The results obtained after seven years are described. Setting - The names of 536 inhabitants with colorectal cancer diagnosed between January 1975 and December 1984 and their relatives' addresses were obtained from the Regione Lombardia Health System records and from the municipal registry offices respectively. Participants - From October 1986 to October 1993, 778 first degree relatives aged 20-75 were offered colonoscopy. Main results - After seven years, 233 (29.9%) had undergone endoscopic examination, mostly up to the splenic flexure. Being > 60 in age at the start of the programme negatively affected participation (p <0.05). Two cancers were detected and adenomatous polyps were found in another 24 of those screened (frequencies: 0.9% and 10.3% respectively). Male gender (p <0.05), increasing age in males (p <0.01), and two or more affected relatives in females (p <0.01) positively affected the frequency of polyps detection. Conclusion - These results suggest that about 30% of the eligible population would comply at least with sigmoidoscopic screening. The collaboration of family doctors and more widespread public information about the ability to cure colorectal cancer are necessary for better compliance.

AB - Study objective - Screening recommendations for colorectal cancer include sigmoidoscopy in asymptomatic, average risk persons aged 50 and over and colonoscopy every three to five years in high risk groups. Little is known about the eligible population's compliance with endoscopic screening. This is the first Italian report of an endoscopic screening programme for colorectal cancer patients) relatives. Design - In 1986, a pilot project for colorectal cancer screening by endoscopy in high risk subjects was started in the Desio (Milan, Italy) public health service region. The results obtained after seven years are described. Setting - The names of 536 inhabitants with colorectal cancer diagnosed between January 1975 and December 1984 and their relatives' addresses were obtained from the Regione Lombardia Health System records and from the municipal registry offices respectively. Participants - From October 1986 to October 1993, 778 first degree relatives aged 20-75 were offered colonoscopy. Main results - After seven years, 233 (29.9%) had undergone endoscopic examination, mostly up to the splenic flexure. Being > 60 in age at the start of the programme negatively affected participation (p <0.05). Two cancers were detected and adenomatous polyps were found in another 24 of those screened (frequencies: 0.9% and 10.3% respectively). Male gender (p <0.05), increasing age in males (p <0.01), and two or more affected relatives in females (p <0.01) positively affected the frequency of polyps detection. Conclusion - These results suggest that about 30% of the eligible population would comply at least with sigmoidoscopic screening. The collaboration of family doctors and more widespread public information about the ability to cure colorectal cancer are necessary for better compliance.

UR - http://www.scopus.com/inward/record.url?scp=0030864887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030864887&partnerID=8YFLogxK

M3 - Article

C2 - 9328557

AN - SCOPUS:0030864887

VL - 51

SP - 453

EP - 458

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

SN - 0143-005X

IS - 4

ER -