Results of a round-robin exercise on read-across

E. Benfenati, M. Belli, T. Borges, E. Casimiro, J. Cester, A. Fernandez, G. Gini, M. Honma, M. Kinzl, R. Knauf, A. Manganaro, E. Mombelli, M. I. Petoumenou, M. Paparella, P. Paris, G. Raitano

Research output: Contribution to journalArticlepeer-review

Abstract

A round-robin exercise was conducted within the CALEIDOS LIFE project. The participants were invited to assess the hazard posed by a substance, applying in silico methods and read-across approaches. The exercise was based on three endpoints: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were assigned for each endpoint and the participants were invited to complete a specific questionnaire communicating their conclusions. The interesting aspect of this exercise is the justification behind the answers more than the final prediction in itself. Which tools were used? How did the approach selected affect the final answer?

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalSAR and QSAR in Environmental Research
DOIs
Publication statusAccepted/In press - May 10 2016

Keywords

  • bioconcentration factor
  • mutagenicity
  • Read-across

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Drug Discovery

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