Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats

Cesare Maltoni, Adriano Ciliberti, Carmine Pinto, Morando Soffritti, Fiorella Belpoggi, Loretta Menarini

Research output: Contribution to journalArticlepeer-review

Abstract

Unleaded gasoline, with high aromatic content, leaded gasoline, gasoil (diesel), kerosene, toluene, xylenes, ethylbenzene, and 1,2,4-trimethyl-benzene were submitted to long-term experimental carcinogenicity bioassays. The mixtures and the compounds were administered by stomach tube, in olive oil, once daily, 4 days weekly, for 104 weeks, to male and female Sprague-Dawley rats. The animals were kept under control until the end of the experiments. With varying degrees of evidence, all the tested materials were found to increase the total number of malignant tumors and of some site-specific tumors. They must therefore be considered carcinogenic. On the basis of our results the rank of carcinogenic potency of the tested aromatic hydrocarbons increases in the following order: 1,2,4-trimethylbenzene, ethylbenzene, xylenes, toluene (benzene).

Original languageEnglish
Pages (from-to)15-52
Number of pages38
JournalAnnals of the New York Academy of Sciences
Volume837
Publication statusPublished - Dec 26 1997

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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