Abstract
Unleaded gasoline, with high aromatic content, leaded gasoline, gasoil (diesel), kerosene, toluene, xylenes, ethylbenzene, and 1,2,4-trimethyl-benzene were submitted to long-term experimental carcinogenicity bioassays. The mixtures and the compounds were administered by stomach tube, in olive oil, once daily, 4 days weekly, for 104 weeks, to male and female Sprague-Dawley rats. The animals were kept under control until the end of the experiments. With varying degrees of evidence, all the tested materials were found to increase the total number of malignant tumors and of some site-specific tumors. They must therefore be considered carcinogenic. On the basis of our results the rank of carcinogenic potency of the tested aromatic hydrocarbons increases in the following order: 1,2,4-trimethylbenzene, ethylbenzene, xylenes, toluene (benzene).
| Original language | English |
|---|---|
| Pages (from-to) | 15-52 |
| Number of pages | 38 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 837 |
| Publication status | Published - Dec 26 1997 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats. / Maltoni, Cesare; Ciliberti, Adriano; Pinto, Carmine; Soffritti, Morando; Belpoggi, Fiorella; Menarini, Loretta.
In: Annals of the New York Academy of Sciences, Vol. 837, 26.12.1997, p. 15-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats
AU - Maltoni, Cesare
AU - Ciliberti, Adriano
AU - Pinto, Carmine
AU - Soffritti, Morando
AU - Belpoggi, Fiorella
AU - Menarini, Loretta
PY - 1997/12/26
Y1 - 1997/12/26
N2 - Unleaded gasoline, with high aromatic content, leaded gasoline, gasoil (diesel), kerosene, toluene, xylenes, ethylbenzene, and 1,2,4-trimethyl-benzene were submitted to long-term experimental carcinogenicity bioassays. The mixtures and the compounds were administered by stomach tube, in olive oil, once daily, 4 days weekly, for 104 weeks, to male and female Sprague-Dawley rats. The animals were kept under control until the end of the experiments. With varying degrees of evidence, all the tested materials were found to increase the total number of malignant tumors and of some site-specific tumors. They must therefore be considered carcinogenic. On the basis of our results the rank of carcinogenic potency of the tested aromatic hydrocarbons increases in the following order: 1,2,4-trimethylbenzene, ethylbenzene, xylenes, toluene (benzene).
AB - Unleaded gasoline, with high aromatic content, leaded gasoline, gasoil (diesel), kerosene, toluene, xylenes, ethylbenzene, and 1,2,4-trimethyl-benzene were submitted to long-term experimental carcinogenicity bioassays. The mixtures and the compounds were administered by stomach tube, in olive oil, once daily, 4 days weekly, for 104 weeks, to male and female Sprague-Dawley rats. The animals were kept under control until the end of the experiments. With varying degrees of evidence, all the tested materials were found to increase the total number of malignant tumors and of some site-specific tumors. They must therefore be considered carcinogenic. On the basis of our results the rank of carcinogenic potency of the tested aromatic hydrocarbons increases in the following order: 1,2,4-trimethylbenzene, ethylbenzene, xylenes, toluene (benzene).
UR - http://www.scopus.com/inward/record.url?scp=0031587502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031587502&partnerID=8YFLogxK
M3 - Article
C2 - 9472329
AN - SCOPUS:0031587502
VL - 837
SP - 15
EP - 52
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -