Risultati della vaccinazione neonatale antiepatite B a frosinone.

Translated title of the contribution: Results of neonatal vaccination against hepatitis B in Frosinone

I. A. Gallo, N. Petrosillo, S. Celletti, I. Tersigni, A. Corbo, L. Antonelli, R. Maddaluno, E. Mancini, A. Ceccarelli, S. Cestra

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neonates born to HBSAg-positive mothers are at increased risk of HBV, mainly because of perinatal exposure. Since 1985 the HBV Regional prevention and control program of Latium recommends prophylaxis both with HBIG and HBV vaccine at birth for all infants born to HBaAg-positive mothers. From 1-1-80 to 1-5-88 89 neonates (52 males, 37 female) from Local Health Units (U.S.L.) FR 2, 3, 4, 5, 6, 7, 8, 9 have been examined at the Centre for Vaccination against HBV of Frosinone. Prophylaxis was accomplished both by HBIG 1 ml. I.M.) at birth and HBV vaccine (5.5 ml. I.M. of HBVAX) at birth, and at 1 and 6 months. All injections were given in the gluteal muscle. Antibody titer to HBsAg (antiHBs) detectable by RIA was tested 1 month after or by the time of the third injection of vaccine. Non-responders (anti HBs less than 10 mUI/ml) were given an extra dose of vaccine (0.5 ml I.M.). 85 neonates accomplished vaccination receiving three injections of HBVAX; 4 neonates received only one dose as their parents refused to continue vaccination. Two neonates (non-responders) out of 85 required another dose of vaccine, but only one seroconvertion appeared. No serious side effects have been seen: one case of anorexia and one case of low-grade fever, with no need to interrupt or modify immunization schedule. In the present study the prophylactic efficacy of HBV vaccine has been demonstrated providing 98.6% of cases with antiHBs titer greater than or equal to 10 mUI/ml, and 84% of cases with antiHBs titer greater than or equal to 150 mUI/ml.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageItalian
Pages (from-to)709-715
Number of pages7
JournalAnnali di igiene : medicina preventiva e di comunità
Volume1
Issue number3-4
Publication statusPublished - May 1989

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Hepatitis B
Vaccination
Vaccines
Newborn Infant
Hepatitis B Surface Antigens
Parturition
Injections
Antibodies
Mothers
Immunization Schedule
Anorexia
Fever
Parents
Muscles
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gallo, I. A., Petrosillo, N., Celletti, S., Tersigni, I., Corbo, A., Antonelli, L., ... Cestra, S. (1989). Risultati della vaccinazione neonatale antiepatite B a frosinone. Annali di igiene : medicina preventiva e di comunità, 1(3-4), 709-715.

Risultati della vaccinazione neonatale antiepatite B a frosinone. / Gallo, I. A.; Petrosillo, N.; Celletti, S.; Tersigni, I.; Corbo, A.; Antonelli, L.; Maddaluno, R.; Mancini, E.; Ceccarelli, A.; Cestra, S.

In: Annali di igiene : medicina preventiva e di comunità, Vol. 1, No. 3-4, 05.1989, p. 709-715.

Research output: Contribution to journalArticle

Gallo, IA, Petrosillo, N, Celletti, S, Tersigni, I, Corbo, A, Antonelli, L, Maddaluno, R, Mancini, E, Ceccarelli, A & Cestra, S 1989, 'Risultati della vaccinazione neonatale antiepatite B a frosinone.', Annali di igiene : medicina preventiva e di comunità, vol. 1, no. 3-4, pp. 709-715.
Gallo IA, Petrosillo N, Celletti S, Tersigni I, Corbo A, Antonelli L et al. Risultati della vaccinazione neonatale antiepatite B a frosinone. Annali di igiene : medicina preventiva e di comunità. 1989 May;1(3-4):709-715.
Gallo, I. A. ; Petrosillo, N. ; Celletti, S. ; Tersigni, I. ; Corbo, A. ; Antonelli, L. ; Maddaluno, R. ; Mancini, E. ; Ceccarelli, A. ; Cestra, S. / Risultati della vaccinazione neonatale antiepatite B a frosinone. In: Annali di igiene : medicina preventiva e di comunità. 1989 ; Vol. 1, No. 3-4. pp. 709-715.
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