Results of re-resection for recurrent thymomas

Jean François Regnard, Franck Zinzindohoue, Pierre Magdeleinat, Lionel Guibert, Lorenzo Spaggiari, Philippe Levasseur

Research output: Contribution to journalArticlepeer-review


Background. The treatment of recurrent thymomas remains controversial. Patients. The place for re-resection was retrospectively studied in 28 consecutive patients operated on during the last 40 years. The initial Masaoka staging of the thymoma was stage I, 4; stage II, 8; stage III, 11; and stage IVa, 3. Postoperatively, 14 have had radiation therapy, 1 chemotherapy, and 13 no adjuvant treatment. Seven patients had development of recurrences, 15 had pleuropulmonary metastases, 5 had both, and 1 had thoracotomy scar recurrence. Nineteen patients had a complete resection and 9 an incomplete one. Results. Most local recurrences appeared after resection of stage I or II thymomas. On the other hand, in patients with stage III or IV thymomas pleural or pulmonary metastases mainly developed. No local recurrence occurred in patients who initially received postoperative radiation therapy. Five-year and 10-year survival rates were 51% and 43%, respectively, for the overall population. Among the 19 patients with complete resection, only 3 patients had a subsequent recurrence; 1 of them could be reoperated on and is still alive and free of disease. Conclusions. Thymoma recurrences often appear as a locoregional rather than a hematogenous spread. Re-resection can be recommended in selected patients.

Original languageEnglish
Pages (from-to)1593-1598
Number of pages6
JournalAnnals of Thoracic Surgery
Issue number6
Publication statusPublished - Dec 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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