Hepatic resection is the treatment of choice for colorectal liver metastases, with 5-year survival rates now approaching 60%. Postoperative morbidity and mortality are constantly decreasing. In particular, 90-day postoperative mortality has been reported in several series to be less than 1%. Several prognostic factors of poor outcome have been recognized but, at present, most of them cannot be used to select patients for resection. Future identification of molecular factors may aid in the prediction of prognosis and help to improve the selection of those patients most likely to benefit from surgery.
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