Results of surgery in children with cerebral cavernous angiomas causing epilepsy

M. Giulioni, N. Acciarri, R. Padovani, E. Galassi

Research output: Contribution to journalArticlepeer-review

Abstract

Epilepsy is the most frequent presenting symptom of cerebral cavernous angiomas or cavernomas, and surgical removal of these vascular malformations is considered the treatment of choice in patients with intractable or long-standing seizures, or in those with poor compliance to medical therapy. In this paper the results of surgical treatment in 11 children with seizures from cerebral cavernomas are reported. Surgery for deep-seated cavernomas was aided in 3 cases by a stereotactic localization technique, that allowed a limited approach with minimal brain damage. Major morbidity and mortality were absent; follow-up ranged between 1 to 16 years. Improved seizure control was seen in all the patients: eight (72%) became seizure-free with the same preoperative therapy; one became seizure-free with a lower drug dosage, and two (18%) were seizure-free without medical therapy. The removal of cavernomas prevented the risk of haemorrhages or further deficits from growth and, above all, avoided spreading and autonomization of the epileptogenic area induced by the cavernoma.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalBritish Journal of Neurosurgery
Volume9
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • Angioma vascular
  • Cerebral cavernous
  • Epilepsy
  • Malformation seizure
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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